XU Bin, CHEN Yong-gang, ZOU Ji-li, et al. Pharmacokinetics of Three Alkaloids in Burn Healing Creams and Its Hydrogels[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 99-102.
DOI:
XU Bin, CHEN Yong-gang, ZOU Ji-li, et al. Pharmacokinetics of Three Alkaloids in Burn Healing Creams and Its Hydrogels[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 99-102. DOI: 10.13422/j.cnki.syfjx.2014110099.
Pharmacokinetics of Three Alkaloids in Burn Healing Creams and Its Hydrogels
Objective:To establish a sensitive and specific HPLC method for determination of plasma concentrations of three alkaloids in rats plasma and compare their bioavailabilities in burn healing ointments and hydrogels. Method:Deep Ⅱ scald model of rats was established
wound were given burn healing ointments and hydrogels with 0.02 g·g-1
respectively.Then plasma concentrations of three alkaloids at different time points were determined by HPLC and major pharmacokinetic parameters were estimated by PKsolver 2.0 software. Result:Concentration-time curves of three alkaloids conformed to a atriovertricular model
in vivo bioavailability of three alkaloids in hydrogels group were superior to ointments group
compared to the latter
the former existed 120%-260% increases in Cmax and 120%-170% increases in AUC0-24 h. Conclusion:This established HPLC method was simple and sensitive to determine concentrations of three alkaloids in rats plasma and could be used for pharmacokinetic analysis;it could find that two dosage forms were quickly absorded and slowly released.
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