Mechanism of Anti-atherogenesis of Shikimic Acid from

HUANG Xiao-ting; YANG Dong-ye; ZHENG Chu; FAN Zhi-min; LIU Man-jun; WEI Gui-ning

doi:10.13422/j.cnki.syfjx.2014110126

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Mechanism of Anti-atherogenesis of Shikimic Acid from

更新时间：2024-01-04

- Mechanism of Anti-atherogenesis of Shikimic Acid from
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 11, Pages: 126-130(2014)
- 作者机构：
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- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014110126
  CLC： R285.5
- Published：2014
- 稿件说明：
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HUANG Xiao-ting, YANG Dong-ye, ZHENG Chu, et al. Mechanism of Anti-atherogenesis of Shikimic Acid from [J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 126-130.
DOI：

HUANG Xiao-ting, YANG Dong-ye, ZHENG Chu, et al. Mechanism of Anti-atherogenesis of Shikimic Acid from [J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 126-130. DOI： 10.13422/j.cnki.syfjx.2014110126.

摘要

目的：探讨八角莽草酸对动脉粥样硬化（AS）大鼠抗氧化系统、炎症因子的水平及ⅡA分泌型血小板型磷脂酶A2（sPLA2-ⅡA） mRNA表达的影响，以了解莽草酸对动脉粥样硬化的作用机制。方法：健康SPF级雄性 Wistar 大鼠72 只，随机分正常对照组、动脉粥样硬化模型组、阳性（辛伐他汀，5 mg·kg-1）对照组、莽草酸低、中、高剂量组（15，30，60 mg·kg-1），高脂饲料加腹腔注射维生素D3法复制动脉粥样硬化模型，灌胃给以莽草酸，24 周后，观察莽草酸对模型大鼠血清超氧化物歧化酶（SOD）活性、丙二醛（MDA）、C反应蛋白（CRP）和血清肿瘤坏死因子α（TNF-α）的水平，主动脉弓sPLA2-ⅡA mRNA表达的影响。结果：与正常组比较，模型组大鼠血清TNF-α，CRP，MDA水平显著增高，SOD的活性显著降低，sPLA2-ⅡA mRNA的表达显著增强。与模型组比较，莽草酸60 mg·kg-1剂量组可显著降低AS大鼠血清TNF-α，CRP水平，分别由模型组的（49.88±22.91）ng·L-1，（10.82±4.33） mg·L-1下降到（28.18±15.95） ng·L-1，（8.17±1.74）mg·L-1 （P<0.05）。莽草酸60 mg·kg-1剂量组可显著降低AS大鼠血清MDA水平，由模型组的（21.55±4.45） μmol·L-1下降到（18.70±1.95） μmol·L-1（P<0.05），可提高SOD的活性，由模型组的（145.81±50.61） U·mL-1提高到（199.87±50.29） U·mL-1 （P<0.05）；莽草酸60，30，15 mg·kg-1剂量组显著下调AS大鼠主动脉弓sPLA2-ⅡA mRNA的表达（P<0.01）。结论：莽草酸可改善AS大鼠炎症状态，且有抗氧化及抑制sPLA2-ⅡA mRNA表达的作用。

Abstract

Objective:To investigate the effects of shikimic acid on antioxidation ability

inflammatory factors and secretory platelet phospholipase A2 of group ⅡA(sPLA2-ⅡA) mRNA in atherosclerosis rats. Method:Seventy-two Wistar rats (n=12) were randomly divided into six group

the normal goup

the model group

the Simvastatin group

high shikimic acid group(60 mg·kg-1)

middle shikimic acid group(30 mg·kg-1) and low shikimic acid group(15 mg·kg-1). Atherosclerosis rats were induced by injected with asingle dose of vitamin D(6×105 U·kg-1)and loaded with high fat diet in order to copy the model. After 24 weeks administration

the serum superoxide-dismutase (SOD)

malondialdehyde (MAD)

tumor necrosis factor-α(TNF-α)and sPLA2-ⅡA mRNA were observed. Result:Compared with normal control group

the serum level of shikimic acid of TNF-α

CRP

MDA

the expression of sPLA2 mRNA of model group was remarkably increased

the actixity of SOD were inhibited(P<0.01

P<0.05).Shikimic acid could reduce the level of serum CRP and TNF-α from(10.82±4.33) mg·L-1 and (49.88±22.91) ng·L-1 of the model group to (8.17±1.74)mg·L-1 and (28.18±15.95) ng·L-1 (P<0.05).Reduce the level of serum MDA from (21.55±4.45) μmol·L-1 of the model group to (18.70±1.95) μmol·L-1 (P<0.05)

and improve the activity of SOD from (145.81±50.61) U·mL-1of the model group to(199.87±50.29) U·mL-1 (P<0.05)

and inhibit the expression of sPLA2-ⅡA mRNA(P<0.01). Conclusion:Shikimic acid can reduce the level of inflammatory factors

improve antioxidation ability

and inhibit the expression of sPLA2-ⅡA mRNA.

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