Protective and Therapy Effect of Compound Chinese Medicine Yiqi Jiedu Huoluo Fang in Rats with Diabetes Nephropathy

YANG Fang; LI Jing-lin; YI Qiu-xia; SHENG Sheng

doi:10.13422/j.cnki.syfjx.2014110165

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Protective and Therapy Effect of Compound Chinese Medicine Yiqi Jiedu Huoluo Fang in Rats with Diabetes Nephropathy

更新时间：2024-01-04

- Protective and Therapy Effect of Compound Chinese Medicine Yiqi Jiedu Huoluo Fang in Rats with Diabetes Nephropathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 11, Pages: 165-169(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014110165
  CLC： R285.5
- Published：2014
- 稿件说明：
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YANG Fang, LI Jing-lin, YI Qiu-xia, et al. Protective and Therapy Effect of Compound Chinese Medicine Yiqi Jiedu Huoluo Fang in Rats with Diabetes Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 165-169.
DOI：

YANG Fang, LI Jing-lin, YI Qiu-xia, et al. Protective and Therapy Effect of Compound Chinese Medicine Yiqi Jiedu Huoluo Fang in Rats with Diabetes Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 165-169. DOI： 10.13422/j.cnki.syfjx.2014110165.

摘要

目的：观察益气解毒活络方对早期糖尿病肾病（diabetic nephropathy，DN）大鼠血流变和纤维蛋白原（Fib）及前列腺素E2（PGE2）的影响。方法：采用高脂高糖饲料喂养合并腹腔注射小剂量链尿佐菌素（streptozocin，STZ）方法建立糖尿病（DM）大鼠模型。以西药盐酸贝那普利作阳性对照，中药干预以益气解毒活络中药复方（12.78 g·kg-1）分别灌胃治疗8，10周。实验结束后，检测大鼠空腹血糖（FBG）、糖化血红蛋白（HbA1c）、血β2微球蛋白（β2-MG）及尿微量白蛋白（MALB）；光镜观察肾组织形态结构变化（HE染色）；血流变仪测定全血黏度（高切、中切、低切）；凝血4项分析仪测定血浆Fib；酶联免疫吸附实验（Elisa法）检测血浆及肾组织PGE2的含量。结果：模型组大鼠FBG，HbA1c及血β2-MG、全血黏度、血浆Fib、尿MALB较正常组明显升高（P<0.05），PGE2含量升高（P<0.05）；与模型组比较，各治疗组大鼠FBG，HbA1c及血β2-MG、全血黏度、血浆Fib、尿MALB显著降低（P<0.05），PGE2含量下降（P<0.05）；模型组大鼠出现明显的肾脏形态学异常，各治疗组肾脏病变明显减轻。结论：DN的发病机制可能与血流变、Fib的异常及PGE2密切相关，益气解毒活络中药复方防治DN的发生发展可能是通过调节血流变、血浆Fib及纠正PGE2的异常实现的。

Abstract

Objective:To investigate the effects of compound Chinese medicine Yiqi Jiedu Huoluo fang on hemorheology and fibrinogen(Fib)

prostaglandin E2(PGE2) level in rats with diabetes nephropathy(DN). Method:The rat model was established by feeding of HG and HF diet with peritoneal injection of streptozocin(STZ).Interfere with benazepril(8 weeks) and herbs(12.78 g·kg-1

10 weeks).Fasting blood-glucose(FBG)

haemoglobin A1c(HbA1c) and β2-microglobulin(β2-MG) and microalbuminuria(MALB)

PGE2(Elisa) were tested.The renal pathological changes were evaluated by HE staining.Observed the changes of hemorheology and Fib

PGE2. Result:The level of FBG

HbA1c

β2-MG

hemorheology and Fib

MALB

PGE2 in the model group were higher obvious(P<0.05)

the other group were lowed.The renal pathological changes were obviously in the model group

and the therapy group were all alleviated. Conclusion:The pathological changes of kidney tissue have a realationship with hemorheology and Fib

PGE2

herbs of Yiqi Jiedu Huoluo fang in percent and cure to diabetic mellitus(DN) may by regulating the abnormal of hemorheology and Fib and PGE2.

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