Maintenance Treatment after Surgical Treatment of Breast Cancer of Fuzheng Xiaoji Decoction to Patients’ Quality of Life and Disease Free Survival Influence

WANG Zheng; YE Xin-ping; ZHANG Hao; LI Wei-han

doi:10.13422/j.cnki.syfjx.2014110203

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Maintenance Treatment after Surgical Treatment of Breast Cancer of Fuzheng Xiaoji Decoction to Patients’ Quality of Life and Disease Free Survival Influence

更新时间：2024-01-04

- Maintenance Treatment after Surgical Treatment of Breast Cancer of Fuzheng Xiaoji Decoction to Patients’ Quality of Life and Disease Free Survival Influence
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 11, Pages: 203-207(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014110203
  CLC： R737.9
- Published：2014
- 稿件说明：
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WANG Zheng, YE Xin-ping, ZHANG Hao, et al. Maintenance Treatment after Surgical Treatment of Breast Cancer of Fuzheng Xiaoji Decoction to Patients’ Quality of Life and Disease Free Survival Influence[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 203-207.
DOI：

WANG Zheng, YE Xin-ping, ZHANG Hao, et al. Maintenance Treatment after Surgical Treatment of Breast Cancer of Fuzheng Xiaoji Decoction to Patients’ Quality of Life and Disease Free Survival Influence[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 203-207. DOI： 10.13422/j.cnki.syfjx.2014110203.

摘要

目的：观察扶正消积方维持治疗乳腺癌术后患者的临床疗效。方法：根据不同的治疗方式将104例乳腺癌术后患者随机分为对照组和观察组。对照组53例给予规范的放疗、化疗、内分泌治疗、靶向治疗及对症支持疗法。观察组51例在对照组治疗的基础上加用扶正消积方辨证治疗，1剂/d，常规水煎分2次服用。3~6个月后，制成膏剂服用。总疗程3年。记录无病生存期（DFS），于治疗前、治疗后6，12个月采用乳腺癌患者生命质量测定量表（QLQ-BR53）评价患者生命质量；分别于治疗前、治疗后6个月采用流式细胞仪检测外周血T淋巴细胞亚群（CD3+，CD4+，CD8+，CD4+/CD8+）及自然杀伤细胞（NK）。结果：对照组复发/转移率为39.62%（21/53），观察组为17.64%（9/51），观察组复发/转移率低于对照组（P<0.05）；对照组无病生存期为（19.7±6.9）个月，低于观察组的（25.8±6.1）个月（P<0.01）；治疗后6个月观察组NK，CD3+，CD4+及CD4+/CD8+高于对照组，CD8+低于对照组（P<0.01）；治疗后6，12个月观察组QLQ-BR53量表的改善均优于对照组（P<0.01）。结论：扶正消积方维持治疗乳腺癌术后改善了患者的近期生命质量，远期延长了复发/转移时间，提高了患者无病生存期。

Abstract

Objective:Observe clinical curative effect of maintenance treatment of Fuzheng Xiaoji decoction to breast cancer after surgical treatment. Method:One hundred and four cases were randomly divided into control group and observation group refer to different treatments.Patients in control group(53 cases) received normative radiotherapy

chemotherapy

endocrinotherapy

targeted therapy and positive symptomatic treatment.Based on the control group

the observation group of (51 cases) the control group the use of Fuzheng Xiaoji decoction based on syndrome differentiation

1 dose/day

conventional water frying

taking 2 times.After 3 to 6 months

taking orally by paste.Total course of treatment was 3 years.Disease free survival(DFS) was recorded

and before treatment

in sixth mouth and twelfth mouth after treatment

patients' quality of life was evaluated by quality of life questionnaire of breast cancer patients(QLQ-BR53).Before treatment

in sixth mouth after treatment

T lymphocyte subset population of peripheral blood(CD3+

CD4+

CD8+

CD4+/CD8+) and natura killer(NK) were detected by flow cytometry. Result:The rate of relapse or migration in control group was 39.62%(21/53)

and in observation group was 17.64%(9/51)

and the rate of relapse or migration in the observation group was lower than the control group(P<0.05).Disease free survival in the control group was(19.7±6.9)mouths lower than the observation group(25.8±6.1)mouths(P<0.01).After 6 mouths of treatment

CD3+

CD4+and CD4+/CD8+ in the observation group were higher than the control group

but CD8+ was lower than the control group(P<0.01).After 6 and 12 mouths of treatment

the improvement of QLQ-BR53 in the observation group were superior to the control group(P<0.01). Conclusion:Maintenance treatment of Fuzheng Xiaoji decoction can ameliorate patients' recent quality of life when it was used to patients after surgical treatment of breast cancer

it can prolong the time of relapse or migration and improve disease free survival of patients.

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