WANG Xing-chun. Multidrug Resistance Reversal Effect of Breast Cancer by Wuweizi Granule Combined with CAF Chemotherapy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(12): 241-243.
DOI:
WANG Xing-chun. Multidrug Resistance Reversal Effect of Breast Cancer by Wuweizi Granule Combined with CAF Chemotherapy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(12): 241-243. DOI: 10.13422/j.cnki.syfjx.2014120241.
Multidrug Resistance Reversal Effect of Breast Cancer by Wuweizi Granule Combined with CAF Chemotherapy
Objective: To observe multidrug resistance reversal and the influence on MRP of breast cancer by Wuweizi granule combined with Cyclophosphamide+Doxorubicin+5-Fluorouracil (CAF)chemotherapy. Method: Seventy-two cases of breast cancer patients of MRP expression were randomly divided into experimental group(36 cases) and control group(36 cases) by hospitalized order. The control group received CAF chemotherapy treatment based on the control group treatment
the experimental group added Wuweizi granule. The two groups were treated for 8 weeks. Observation two groups of the clinical efficacy
survival time
median remission
side effects and reversal effective rate of MRP in the two groups were observed after the treatment. Result: The total efficiency of the experimental group 58.33%
was higher than the control group 30.56%(P<0.05).The median remission of the experimental group 12.5 months was better than the control group 7.5 months(P<0.05). The reversal effective rate of MRP in the experimental group 33.3%
was significantly higher than the control group 2.78% (P<0.05). Conclusion: Wuweizi granule combined with CAF chemotherapy can effectively alleviate the clinical effects of breast cancer patients
which can effectively reverse multidrug resistance by MRP
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