HU Peng-yi, GONG Ying-ying, ZHENG Qin, et al. Investigation of Stability of Compound Danshen Powders with Different Particle Sizes[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 1-7.
DOI:
HU Peng-yi, GONG Ying-ying, ZHENG Qin, et al. Investigation of Stability of Compound Danshen Powders with Different Particle Sizes[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 1-7. DOI: 10.13422/j.cnki.syfjx.2014130001.
Investigation of Stability of Compound Danshen Powders with Different Particle Sizes
Objective: To investigate influence of surperfine grinding on stability of index components in compound Danshen powders under high temperature
high humidity and light conditions
respectively. Method: Compound Danshen powders with different particle sizes were prepared
taking comprehensive change rate of index components as index
after exposed them to high humidity
high temperature and light for five and ten days
HPLC was empolyed to determine content change of index components in compound Danshen powders with different particle sizes. Result: Under condition of high moisture
contents of cryptotanshinone and salvianolic acid B decreased much more among different compound Danshen powders
coarse powder decreased most
micropowder Ⅱ decreased least.High temperature had more obvious effect on tanshinone Ⅰ
tanshinol and salvianolic acid B
micropowder Ⅰ changed most
micropowder Ⅱ changed least.Light had most obvious effect on all index components
coarse powder changed most
micropowder Ⅱ changed least.Index components of Notoginseng Radix et Rhizoma from compound Danshen powders were stable after being exposed to high humidity
high temperature and light. Conclusion: Light had the greatest effect on index components in compound Danshen powders with different particle sizes
which showed that these powders should be stored away from light.With decreasing of particle size
stability of compound Danshen powders showed tendency of becoming better and then worse