Objective: To prepare Belladonnae Herba dispersible tablets and establish a method for determination of its dissolution. Method: Taking cross-linked polyvinylpyrrolidone(PPVP)+sodium carboxymethyl starch(CMS-Na) inside and outside addition as disintegrating agents

calcium hydrogen phosphate

sucrose and CMS-Na as fillers

60% ethanol solution containing 5% hydroxypropyl methyl cellulose(HPMC) as adhesives

microcrystalline cellulose as glidants

talcum powder as lubricants

HPLC was adopted to determine dissolution of Belladonnae Herba dispersible tablets with mobile phase of acetonitrile-methanol-0.01 mol·L-1 phosphate solution containing 0.005 mol·L-1 sodium heptanesulfonate(potassium dihydrogen phosphate-dibasic potassium phosphate 1:1)(25:10:65) and detection wavelength at 211 nm. Result: Atropine sulfate showed a linear relationship in the range of 0.003 38-0.026 624 μg

RSD of precision was 1.29%

average recovery was 99.76% with RSD of 0.86%.Dissolutions of Belladonnae Herba dispersible tablets in 2

5

10

15

30 and 45 min were 0%

15.29%

25.74%

40.40%

67.42% and 73.30%

respectively.Dissolution of ordinary Belladonnae Herba tablets was 23.22% within 45 min. Conclusion: These prepared Belladonnae Herba dispersible tablets had good uniformity.This determination was simple

accurate and suitable for quality control of this product.