Transdermal Test of Alkaloids from Plastics

LI Jun; GUO Chao; HAN Mei; GAO Li-li; LENG Xiao-hong

doi:10.13422/j.cnki.syfjx.2014130045

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Transdermal Test of Alkaloids from Plastics

更新时间：2024-01-04

- Transdermal Test of Alkaloids from Plastics
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 13, Pages: 45-47(2014)
- 作者机构：
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- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014130045
  CLC： R284.1
- Published：2014
- 稿件说明：
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LI Jun, GUO Chao, HAN Mei, et al. Transdermal Test of Alkaloids from Plastics[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 45-47.
DOI：

LI Jun, GUO Chao, HAN Mei, et al. Transdermal Test of Alkaloids from Plastics[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 45-47. DOI： 10.13422/j.cnki.syfjx.2014130045.

摘要

目的：优选苦豆子生物碱涂膜剂的体外透皮试验条件。方法：利用UV测定苦豆子生物碱含量，检测波长410 nm。选择奶牛乳房皮肤，通过Franz垂直扩散池法考察苦豆子生物碱涂膜剂的透皮性能，考察甘油、氮酮及两者合用对该涂膜剂透皮吸收的影响。结果：不同促渗剂对苦豆子生物碱的促透作用顺序为5%氮酮+3%甘油>3%氮酮+3%甘油>8%氮酮>5%氮酮>3%氮酮>3%甘油>1%甘油>1%氮酮，透皮吸收速率最高达62.96 μg·cm-2·h-1。结论： 5%氮酮联合3%甘油可显著增加苦豆子生物碱涂膜剂的透皮性能。

Abstract

Objective: To optimize in vitro transdermal test conditions of alkaloids from Sophora alopecuroides plastics. Method: UV was adopted to determine the content of alkaloids from S. alopecuroides wtih detection wavelength at 410 nm.Utilized skin on udder

franz vertical diffusion cell was adopted to investigate transdermal absorption of alkaloids from S. alopecuroides plastics

effects of azone

glycerol and combination of both of them on transdermal absorption of this plastics was investigated. Result: Effect of enhancers on alkaloids from S. alopecuroides was in order of 5% azone+3% glycerol>3% azone+3% glycerol>8% azone>5% azone >3% azone>3% glycerol>1% glycerol>1% azone

transdermal absorption rate was up to 62.96 μg·cm-2·h-1. Conclusion: Combination of azone and glycerol could significantly increase percutaneous permeability of alkaloids from S. alopecuroides plastics.

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