Chemical Components from Qili Qiangxin Capsule (Ⅲ)

QIAO Li; WANG Zong-quan; CAI Yan; MENG Zuo-huan; WANG Gui-jin; JIA Ji-ming; SONG Jian

doi:10.13422/j.cnki.syfjx.2014130106

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Chemical Components from Qili Qiangxin Capsule (Ⅲ)

更新时间：2024-01-04

- Chemical Components from Qili Qiangxin Capsule (Ⅲ)
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 13, Pages: 106-109(2014)
- 作者机构：
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- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014130106
  CLC： R286.0
- Published：2014
- 稿件说明：
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QIAO Li, WANG Zong-quan, CAI Yan, et al. Chemical Components from Qili Qiangxin Capsule (Ⅲ)[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 106-109.
DOI：

QIAO Li, WANG Zong-quan, CAI Yan, et al. Chemical Components from Qili Qiangxin Capsule (Ⅲ)[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 106-109. DOI： 10.13422/j.cnki.syfjx.2014130106.

摘要

目的：研究复方中药芪苈强心胶囊的化学成分，从而明确芪苈强心胶囊的药效物质基础。方法：使用硅胶柱色谱、凝胶柱色谱、中低压液相色谱和制备高效液相色谱等手段，对芪苈强心胶囊大孔树脂95%，50%，30%醇洗部分的化学成分进行分离和鉴定。结果：从这三段洗脱物中分离纯化得到10个单体化合物。利用1D，2D核磁共振光谱全部鉴定了其结构。分别为人参皂苷Rd（1），20（S）-人参皂苷Rh1（2），20（S）-人参皂苷Rg2（3），毛蕊异黄酮（4），杠柳苷Δ5-pregnene-3β，20（S）-diol-20-O-β-D-glucopyranosyl-（1→6）-β-D-glucopyranosyl-（1 →2）-β-D-digitalopyranoside（5），黄芪皂苷Ⅰ（6），山柰酚-3-O-β-D-芸香苷（7），橙皮苷（8），迷迭香酸甲酯（9），迷迭香酸乙酯（10）。结论：化合物 1~6，8~10 均为首次从芪苈强心胶囊中分离得到。

Abstract

Objective: To study the chemical components of Qili Qiangxin capsule and to prove its material basis for efficacy. Method: The compounds were isolated from fractions eluted by 95% ethanol

50% ethanol and 30% ethanol on silica gel

sephadex LH-20

MPLC and PHPLC repeatedly. Result: Ten compounds were isolated and their structures were elucidated on the basis of chemical methods and spectral analyses. They were identified as ginsenoside Rd (1)

20(S)-ginsenoside Rh1 (2)

20(S)-ginsenoside Rg2 (3)

calycosin (4)

Δ5-pregnene-3β

(S)-diol-20-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-digitalopyranoside (5 )

astragaloside I (6)

kaempferol-3-O-β-D-rutinoside (7)

narirutin (8)

methyl rosmarinate (9) and ethyl rosmarinate (10). Conclusion: The compounds 1-6

8-10 are identified from Qili Qiangxin capsule for the first time.

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