Therapeutic Effect of Kangbai Decoction on Experimental Vitiligo Guinea Pigs

AI Ying; YU Guo-hua

doi:10.13422/j.cnki.syfjx.2014130152

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Therapeutic Effect of Kangbai Decoction on Experimental Vitiligo Guinea Pigs

更新时间：2024-01-04

- Therapeutic Effect of Kangbai Decoction on Experimental Vitiligo Guinea Pigs
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 13, Pages: 152-156(2014)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2014130152
  CLC： R285.5
- Published：2014
- 稿件说明：
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AI Ying, YU Guo-hua. Therapeutic Effect of Kangbai Decoction on Experimental Vitiligo Guinea Pigs[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 152-156.
DOI：

AI Ying, YU Guo-hua. Therapeutic Effect of Kangbai Decoction on Experimental Vitiligo Guinea Pigs[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 152-156. DOI： 10.13422/j.cnki.syfjx.2014130152.

摘要

目的：研究抗白汤对实验性白癜风豚鼠的治疗作用。方法：采用5%氢醌制备实验性白癜风豚鼠模型，以白癜风胶囊（0.24 g·kg-1）作对照，分别用低、中、高剂量（3.1，6.2，12.4 g·kg-1）抗白汤灌胃，每天1次，连续50 d，相当于造模时间5倍治疗。肉眼观察各药物组治疗实验性白癜风豚鼠模型的疗效，并观察表皮基底细胞和棘细胞黑色素分布以及对豚鼠模型血液中胆碱酯酶（CHE）、单胺氧化酶（MAO）、丙二醛（MDA）含量的影响；各药物组对豚鼠模型黑色素吸光度及酪氨酸酶含量和血液流变学各项指标的影响。结果：造模后，模型组血浆黏度、全血黏度，CHE，MAO，MDA含量明显升高，毛囊中黑色素数量、吸光度以及酪氨酸酶含量明显减少，与正常组比较均有显著性差异（P<0.01）。抗白汤各剂量组与模型组比较，能显著增加皮肤表皮基底细胞和棘细胞黑色素分布和皮肤毛囊中黑色素（P<0.01），能显著增强黑色素的吸光度以及增加酪氨酸酶的含量（P<0.01），能显著降低血液中CHE，MAO，MDA含量（P<0.01），能显著改善血浆黏度及全血黏度（P<0.01），并呈现良好的量-效关系，与白癜风胶囊组比较也有显著性差异（P<0.05）。结论：抗白汤对实验性白癜风豚鼠模型具有良好的治疗作用，其主要机制可能与促进血液循环，降低血液中CHE，MAO，MDA含量和增加酪氨酸酶含量，增加毛囊中黑色素数量，增加其吸光度等有关。

Abstract

Objective: To study the therapeutic effect of Kangbai decoction on experimental vitiligo guinea pigs induced. Method: The experimental vitiligo guinea pig model was prepared by 5% hydroquinone. vitiligo capsule (0.24 g·kg-1) as control group

low

moderate and high dose (3.1

6.2

12.4 g·kg-1) of Kangbai decoction were orally given once a day for 50 days. The epidermal basal and prickle cell melanin distribution as well as the cholinesterase (CHE)

monoamine oxidase (MAO)

malondialdehyde (MDA) content were observed.The indexes of blood rheology

the content of tyrosinase and absorbance of melanin were measured. Result: After modeling

the whole blood viscosity and plasma viscosity and CHE

MAO and MDA of the model group were obviously increased. The melanin distribution and skin hair follicle melanin of skin epidermal basal and prickle cell

absorption of melanin and tyrosinase content were significantly decreased. Compared with the normal group (P<0.01). Kangbai decoction could significantly increased the melanin distribution and skin hair follicle melanin of skin epidermal basal and prickle cell(P<0.01). The absorption of melanin and tyrosinase content were increased.CHE

MAO and MDA content were decreased in the blood and improved the indexes of blood rheology obviously(P<0.01). Conclusion: Kangbai decoction had a good therapeutic effect on experimental vitiligo guinea pigs

and its main mechanisms may be related to promoting blood circulation

reducing blood CHE

MAO and MDA content and increasing the content of tyrosinase melanin

increasing the number of hair follicles and absorbance etc.

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Related Institution

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