MA Qian-qian, LI Jin-ping, WU Li, et al. Effect of Breviscapine on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 176-179.
DOI:
MA Qian-qian, LI Jin-ping, WU Li, et al. Effect of Breviscapine on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 176-179. DOI: 10.13422/j.cnki.syfjx.2014130176.
Effect of Breviscapine on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus Rats
Objective: To study the effect of breviscapine on glucose and lipid metabolism in type 2 diabetes mellitus(T2DM) rats. Method: The T2DM model rats were induced by feeding of high-fat and high-carbohydrate diet and injecting streptozotocin and then were randomly divided into the model group(MG)
the low and high dose group(100
200 mg·kg-1·d-1
LG
HG)
A normal control group was also set up(NG). The drugs were given for 14 days by intraperitoneal injection. Then the general status
the fasting blood glucose (FBG)
insulin(INS)
blood lipid [total cholesterol(TC)
triglycerides(TG)
and low-density lipoprotein cholesterol(LDL-C)] and adiponectin(APN) levels were compared between each group. The rat pancreatic tissue pathological section were also made. Result: Compared with NG
there were obvious symptoms of diabetes in MG
levels of FBG
INS
TC
TG
LDL-C significantly increased and levels of APN decreased in MG(P<0.01).Compared with MG
the general status improved in both LG and HG
levels of FBG
INS
TC
TG
LDL-C significantly decreased and levels of APN increased in both LG and HG(P<0.01 or P<0.05). Conclusion: Breviscapine may adjust the disturbance in the glucose and lipid metabolism by improving the low adiponectin levels and insulin resistance in T2DM rats.
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