Objective: The purpose is to discuss the clinical effects of Qianyang Huoxue Tongluo decoction in treating of acute cerebral infarction patients and influence of fibrinolytic system. Method: Seventy-six patients were randomly divided into control group (38 cases) and observation group (38 cases)by random number table.Both groups received conventional western medicine treatment according to guideline of 2010 Chinese acute ischemic cerebral infarction

including controlling blood pressure

blood glucose

body temperature

anticoagulation and restraining blood platelet.Patients in control group taken aspirin enteric-coated tablets.Taken orally.For patients in observation group added Qianyang Huoxue Tongluo decoction based on the treatment of control group

1 does/day.Treatment courses of two groups continued 14 days.Use clinical neurological function deficit scores (CSS scores) to evaluate the degree of nerve damage.Adopt Fugl-Meyer campaign function test (FMI) to assess movement function.Use improved Ashworth spasm rating chart to estimate the degree of limb spasm.Employ developing substrate method to examine the content of tissue plasminogen activator(t-PA) and plasminogenemia activator inhibitor(PAI).Adopt immune turbidimetric method to detectfibrinogen(FIB).Use enzyme-linked immunosorbent method to test D-dimer(D-D) and von willebrand factor (vWF).The indexes above each take one evaluation before and after treatment. Result: CSS scores and improve Ashworth scores of both groups declined after treatment.The data of observation group was lower than the control group(P<0.01).After treatment

FMI scores of both group increased.Besides the data of observation group was superior to the control group(P<0.01).Both groups' levels of t-PA and PAI reduce which in the observation group was lower than in the control group(P<0.01).After treatment

the level of plasma FIB

D-D and vWF was falling(P<0.01).For observation group the level of plasma FIB

D-D and vWF was inferior to which in control group(P<0.01).The total effective rate in the observation group was 92.11% superior to 73.68% in the control group(P<0.05). Conclusion: Qianyang Huoxue Tongluo decoction can effectively dissolve thrombus and inhibit thrombosis by means of adjusting the fibrinolytic system function.Through this it was able to improve the blood supply of the lesion site and promote the recovery of neurological function.