Objective: The purpose of this research lies in the evaluation of efficacy and safety of the anti-inflammatory moisturizing lotion in treating atopic dermatitis(AD). Method: The cases who have symmetrical and similar severity(severity score differs less than two) lesions on the limbs. Basic moisturizer was applied in both treatment side and control side

whereas anti-inflammatory moisturizing lotion was added to the treatment side

but control side not for 2 weeks. The clinical efficacy and safety were observed. Result: After 2 weeks

the score of the treatment target lesions and the control lesions had significant statistical difference (P<0.01)

both the scores of the local pruritus had significant statistical difference (P<0.01) which indicated that the anti-inflammatory moisturizing lotion could effectively improve the skin lesions and reduce pruritus. The total score and the pruritus score of target lesions decreased more significantly than the control lesions. Target lesions of acute and chronic lesions compared with total score was significant (P<0.05)

which shows that the acute lesions give a more significant improvement compared with the chronic lesions. Thus using anti-inflammatory moisturizing lotion in acute inflammatory has a better outcome. There is not any uncomfortable sensation in those patients with mild to moderate in severity 4 cases of severe AD patients felt mild to moderate bearable burning and stinging on the skin. Conclusion: Anti-inflammatory moisturizing lotion can greatly improve lesion conditions and pruritus. Using anti-inflammatory moisturizing lotion in acute inflammatory has a better outcome compared with those chronic lesions in a 2 week's period of treatment. Anti-inflammatory moisturizing lotion is formulated according to the pathogenesis of‘flare-up of heart fire

insufficiency of spleen with dampness’

by using the‘purging the heart fire and tonify the spleen’method

it is suitable for both acute and remitting phases

anti-inflammation

inhibiting the plantation of staphylococcus and infection might be major mechanism. Anti-inflammatory moisturizing lotion is safe. Evaluating severity of lesions and sensitivity

regulating medication concentration

time and temperature when using

and maintain skin moisturization after applying the lotion

will greatly decrease side effects.