HUANG Ping, XIA Hou-lin, JIA Fang, et al. Influence of Benzoinum and Borneolum Syntheticum on Pharmacokinetics of Benzoic Acid and Cinnamic Acid in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(15): 118-121.
DOI:
HUANG Ping, XIA Hou-lin, JIA Fang, et al. Influence of Benzoinum and Borneolum Syntheticum on Pharmacokinetics of Benzoic Acid and Cinnamic Acid in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(15): 118-121. DOI: 10.13422/j.cnki.syfjx.2014150118.
Influence of Benzoinum and Borneolum Syntheticum on Pharmacokinetics of Benzoic Acid and Cinnamic Acid in Rats
Objective: To study the pharmacokinetics of benzoic acid and cinnamic acid in rats plasma after oral administration of Benzoinum liquid or the mixing liquid of Benzoinum and Borneolum Syntheticum. Method: SD rats were divided into two groups randomly
giving Benzoinum liquid or the mixing liquid of Benzoinum and Borneolum Syntheticum respectively
collecting the plasma samples at different time. Then determining benzoic acid and cinnamic acid contents
and calculating the pharmacokinetic parameters. Result: The experiments showed the Tmax were (41.57±1.99)
(11.42±3.78)min for benzoic acid
(32.86±3.13)
(11.71±2.96)min for cinnamic acid. The maximum plasma concentration(Cmax) were(34.93±11.65)
(40.35±22.72) mg·L-1 for benzoic acid
(2.96±1.10)
(3.43±1.38)mg·L-1 for cinnamic acid. The AUC(0~∞) were (4 481.42±879.21)
(3 942.21±977.52)min·μg-1·mL-1 for benzoic acid (601.16±45.84)
(401.33±23.35)min·μg-1·mL-1 for cinnamic acid. Conclusion: In the compatibility of Benzoinum with Borneolum Syntheticum the Tmax of benzoic acid and cinnamic acid were significantly reduced
suggesting that the compatibility of the two drugs can accelerate the absorption speed of benzoic and cinnamic acid in rats.
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