Objective: The study was designed to explore the molecular biological mechanism of the innovation model(unique formula

different particles

paste medication way) that Fufang Xiyi powder different particles combination agent(XY). Method: Twenty rats were as control group

the other rats were given 0.02 mol·L-1 N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) to induce precancerous leisions of gastric cancer(PLGC)model

the modeling rats were randomly divided into5 groups:model control group

80 mesh group

100 mesh group

80 mesh and 100 mesh mixing equal treatment group

Vitacoenzyme treatment group

13 rats each group.Munohisto chemical method was used to detect the B-cell lymphoma/leuke-2(Bcl-2)and survivin protein expression of gastrictissue. Result: The average optical density (A) value of Bcl-2 and Survivin in gastric tissue in each group rats was:normal control group(19.06±2.32/21.46±2.69)

model control group(30.20±4.83/29.29±3.51)

80 mesh group(22.14±3.57/24.18±2.82)

100 mesh group(21.98±3.06/24.05±2.80)

80 mesh and 100 mesh mixing equal treatment group(19.15±2.67/21.63±2.61)

Vitacoenzyme treatment group(24.80±2.89/26.59±3.36) model control group compared with normal control group was notable differences between them (P<0.05). Each treatment group compared with model control group showed notable differences (P<0.05)

each treatment group of Fufang Xiyi powder compared with Vitacoenzyme treatment group was significantly lower(P<0.05)

the A values of 80 mesh and 100 mesh mixing equal treatment group was the lowest

and that was significantly lower than 80 mesh group and 100 mesh group(P<0.05).The expression of survivin protein was positively correlated with that of Bcl-2 protein(r=0.935

P<0.05). Conclusion: The expression of Bcl-2 and Survivin proteins found in this study indicats a synergistic effect among PLGC. The innovation model of Fufang Xiyi powder different particles combination agent may further down-regulate antiapoptosis gene Bcl-2 and survivin to achieve effective intervention of PLGC and delay the process of carcinogenesis.