Research on Acute and Mutagenic Toxic Effects of Active Ingredients Assembling of Chinese Herbs for Antioxidant Activity

YANG Hong; WU Yan; LIU Zhao; ZHONG Ju-ying; GAO Er-ning; WANG Ping-juan; HUANG Dong-ye; TIAN Zhao-fu

doi:10.13422/j.cnki.syfjx.2014150185

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Research on Acute and Mutagenic Toxic Effects of Active Ingredients Assembling of Chinese Herbs for Antioxidant Activity

更新时间：2024-01-04

- Research on Acute and Mutagenic Toxic Effects of Active Ingredients Assembling of Chinese Herbs for Antioxidant Activity
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 15, Pages: 185-189(2014)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2014150185
  CLC： R285.1
- Published：2014
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YANG Hong, WU Yan, LIU Zhao, et al. Research on Acute and Mutagenic Toxic Effects of Active Ingredients Assembling of Chinese Herbs for Antioxidant Activity[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(15): 185-189.
DOI：

YANG Hong, WU Yan, LIU Zhao, et al. Research on Acute and Mutagenic Toxic Effects of Active Ingredients Assembling of Chinese Herbs for Antioxidant Activity[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(15): 185-189. DOI： 10.13422/j.cnki.syfjx.2014150185.

摘要

目的：根据前期中药组分配伍的抗氧化活性研究结果，采用甘草总黄酮、银杏叶提取物、淫羊藿苷、黄芪总苷和麦冬总皂苷组成中药有效组分最优配伍复方，研究该复方的急性毒性和致突变作用，为其进一步应用的安全性提供理论依据。方法：应用急性毒性试验、小鼠骨髓嗜多染红细胞微核试验、小鼠骨髓细胞染色体畸变试验和Ames试验检测该组分配伍复方的急性毒性和致突变性。结果：急性经口毒性试验，雌性、雄性小鼠经口最大耐受量（MTD）均>10 g·kg-1，属实际无毒。小鼠骨髓嗜多染红细胞微核试验、小鼠骨髓细胞染色体畸变试验和Ames试验结果均为阴性，显示在本实验条件下，该中药组分复方未见有致突变性作用。结论：中药组分配伍复方未见有明显的急性毒性和致突变作用，表明该药物安全性良好。

Abstract

Objective: To evaluate the acute and mutagenic toxic effects of the active ingredients assembling of Chinese herbs for antioxidant activity. Chinese herbal active ingredient formula was composed of total flavonoids of Glycyrrhiza

ginkgo biloba extract

total flavonoids of epimedium

astragaloside and total saponins in ophiopogonin. Method: Acute oral toxicity test

marrow cell micronucleus test polychromatic erythrocyte(PCE)

marrow chromosomal aberration test of mice and Ames were tested. Result: Mice acute oral maximum tolerated dose(MTD) of the formula was higher than 10 g·kg-1. The micronucleus rates in all doses were not significantly different from the control group. Negative results were seen form chromosome aberration test. No increase in the number of revertant colonies was found in the Ames test with and without S9 activation system. Conclusion: The Chinese herbal active ingredient formula has no toxic substance and mutagenicity effects in this study.

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