Fuzheng Kanglao Decoction Assisted for Treatment of Newly Diagnosed 114 Cases of Secondary Pulmonary Tuberculosis

WU Yu-zhuo; ZHANG Huai-hong; HUO Li-ya

doi:10.13422/j.cnki.syfjx.2014150190

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Fuzheng Kanglao Decoction Assisted for Treatment of Newly Diagnosed 114 Cases of Secondary Pulmonary Tuberculosis

更新时间：2024-01-04

- Fuzheng Kanglao Decoction Assisted for Treatment of Newly Diagnosed 114 Cases of Secondary Pulmonary Tuberculosis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 15, Pages: 190-194(2014)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2014150190
  CLC： R259
- Published：2014
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WU Yu-zhuo, ZHANG Huai-hong, HUO Li-ya. Fuzheng Kanglao Decoction Assisted for Treatment of Newly Diagnosed 114 Cases of Secondary Pulmonary Tuberculosis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(15): 190-194.
DOI：

WU Yu-zhuo, ZHANG Huai-hong, HUO Li-ya. Fuzheng Kanglao Decoction Assisted for Treatment of Newly Diagnosed 114 Cases of Secondary Pulmonary Tuberculosis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(15): 190-194. DOI： 10.13422/j.cnki.syfjx.2014150190.

摘要

目的：探讨扶正抗痨方辅助化疗对初治继发性肺结核的增效减毒及对免疫功能的调节作用。方法：226例患者采用随机按数字法分为对照组112例和观察组114例。对照组口服异烟肼，0.3 g/次，1次/d；利福平，0.45～0.60 g/次，1次/d，空腹顿服；吡嗪酰胺，1.5 g/次，1次/d；乙胺丁醇，0.75～1.0 g/次，1次/d。观察组在对照组治疗的基础上加用扶正抗痨方，1剂/d。两组疗程均为6个月。每月监测痰菌、肝功能；于治疗前及治疗后2，4，6个月对症状、体征进行评价；采用流式细胞仪检测治疗前后外周血T淋巴细胞亚群；进行治疗前后生活质量评价。结果：观察组治愈率为85.96%优于对照组的73.77%（P<0.05）；观察组肺部阴影明显吸收率为77.19%，优于对照组的65.18%（P<0.05）；治疗后2，4，6个月，观察组主要症状、体征评分均低于对照组（P<0.01）；治疗后观察组生理、心理，社会关系、生存质量主观感觉及健康状况主观感觉评分等维度评分较治疗前上升（P<0.01），治疗后观察组上述维度评分均高于对照组（P<0.01）；治疗后观察组CD3+，CD4+和CD4+/CD8+高于对照组，CD8+低于对照组（P<0.01）；对照组肝功能异常发生率为20.5%，观察组为9.6%，观察组低于对照组（P<0.05）。结论：扶正抗痨方辅助化疗治疗初治继发性肺结核能起到增效减毒作用，并能提高患者生活质量；扶正抗痨方还能调节患者细胞免疫功能，从而有利于机体发挥对抗细菌的清除作用。

Abstract

Objective: To dicuss synergism and attenuation of Fuzheng Kanglao decoction assisted chemotherapy for initial treatment of secondary pulmonary tuberculosis and observe its adjust function to cellular immunity. Method: Two hundred and twenty-six cases were randomly divided into control group(112 cases) and observation group(114 cases) by digital method.Patients in the control group received isoniazide with 0.3 g/time and 1 time/day

rifampicin with 0.45-0.6 g/time

taken on an empty stomach

pyrazinamide with 1.5 g/time and 1 time/d

ethambutol with 0.75-1.0 g/time and 1 time/d.Based on treatment of the control group

patients in the observation group added Fuzheng Kanglao decoction with 1 dose/day.Course of treatment in those two groups were both 1 months.Sputum bacteria and liver function were detected every month.Before treatment and at the second

fourth and sixth months

scores of main symptoms and signs in the observation group were evaluated.Before and after treatment

T-lymphocyte subpopulation of peripheral blood detected by flow cytometry and quality of life also was detected. Result: Cure rate in the observation group was 85.96% superior to 73.77% in the control group(P<0.05).Pulmonary shadows absorption in the observation group was 77.19% superior to 65.18% in the control group(P<0.05).At the second

forth and sixth months after treatment

scores of main symptoms and signs in the observation group were lower than those in the control group(P<0.01).After treatment

dimension scores of physiology

mentality

social relations

subjective feeling of quality of life and state of health increased(P<0.01)

and which in the observation group were higher than those in the control group(P<0.01)

CD3+

CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group

but CD8+ was lower than in the control group(P<0.01).Occurrence rate of abnormal liver function in the observation group was 9.6% lower than 20.5% in the control group(P<0.05). Conclusion: Fuzheng Kanglao decoction assisted chemotherapy had function of synergism and attenuation for initial treatment of secondary pulmonary tuberculosis

and it could improve patients' quality of life.Fuzheng Kanglao decoction could adjust function of patients' cellular immunity and contribute bodies to coping with scavenging action of germ.

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