Advances in Research on Processing and Toxicology Reduction of Aconiti Lateralis Radix Praeparata

CHEN Rong-chang; SUN Gui-bo; ZHANG Qiang; SUN Xiao-bo

doi:10.13422/j.cnki.syfjx.2014150237

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Advances in Research on Processing and Toxicology Reduction of Aconiti Lateralis Radix Praeparata

更新时间：2024-01-04

- Advances in Research on Processing and Toxicology Reduction of Aconiti Lateralis Radix Praeparata
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 15, Pages: 237-241(2014)
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2014150237
  CLC： R283
- Published：2014
- 稿件说明：
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CHEN Rong-chang, SUN Gui-bo, ZHANG Qiang, et al. Advances in Research on Processing and Toxicology Reduction of Aconiti Lateralis Radix Praeparata[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(15): 237-241.
DOI：

CHEN Rong-chang, SUN Gui-bo, ZHANG Qiang, et al. Advances in Research on Processing and Toxicology Reduction of Aconiti Lateralis Radix Praeparata[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(15): 237-241. DOI： 10.13422/j.cnki.syfjx.2014150237.

摘要

通过查阅近年关于附子炮制减毒的研究文献，分别概述了附子炮制工艺及检验标准，对附子炮制作用及机制进行了深入探讨。附子药用历史悠久，应用广泛，对多种急症、重症疗效独特。但附子毒性较大，具有明显的心脏毒性和神经毒性。因其毒性剧烈可致人死亡，所以炮制减毒对附子应用非常重要。附子炮制之法自古有之，主要有火制法的炮、烧、炒、炙、蒸、煮等；辅料制法的醋制、蜜制、姜汁制、童便制、甘草制等。随着现代技术的发展，又有许多新的炮制方法出现，但没有一个统一的检验标准，《中国药典》采用乌头碱限量法对附子的炮制进行定性的检测。附子毒性在经加工炮制后得到缓解，便于内服。炮制品附片、黑顺片、白附片可直接入药。附子炮制减毒的机制主要是在炮制过程中各种类型的生物碱均被破坏或流失。剧毒性的双酯型乌头碱水解成苯甲酰单酯型生物碱，进而水解成醇胺类乌头原碱类生物碱。附子在考虑炮制去毒的同时，还要重视有效成分的含量，如何能达到减毒增效的目的，依然是一个难题。研究附子的毒性机制及其炮制过程中化学成分的变化，找到更好的减毒途径，达到减毒增效的目的，对其应用具有重要意义。本文就附子炮制现代技术及机制研究进行整理，希望对附子的炮制减毒、临床应用提供参考。

Abstract

The review outline Aconiti Lateralis Radix Praeparata processing technology in present and inspection standards respectively and analysis Aconiti Lateralis Radix Praeparata processing mechanism thoroughly. Aconiti Lateralis Radix Praeparata is used widely in traditional Chinese medicine to treat various disease mainly about the cardiovascular system. Processing and toxicology reduction of Aconiti Lateralis Radix Praeparata is very important because of its large toxicology

Because of its severe toxicity can cause death. The method of fuzi processing originated from ancient time and there are many new processing methods appeared. However

there has been no measure standard. Aconitine limited method was used to examine processing in ‘Chinese pharmacopoeia’. The toxicity of fuzi decreased after processing. Processed aconite

heishunpian

white monkshood can be directly used as medicine. The mechanism of Aconiti Lateralis Radix Praeparata processing attenuated its toxicity is mainly that various types of alkaloids were destroyed and loss in the processing. Toxic diester aconitum hydrolysis into benzoyl ester type alkaloids

then hydrolyzed hydrolysis into alcohol amine aconine alkaloids. Although our objective is to reduce the toxicity of Aconite Lateralis Radix Praeparata

the content of effective components should also be taken consideration. It is still difficult to decrease toxicity and keep effective functions at the same time. Changes in chemical composition during processing is important to study the mechanism of aconite processing. This paper summarize the processing methods of Aconiti Lateralis Radix Praeparata and the mechanism of toxicology reduction

which can serve as a reference for study on Aconiti Lateralis Radix Praeparata processing and clinical using.

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