Optimization of Matrix Formulation for Fumikang Gels by Central Composite Design-response Surface Methodology

YE Hai-na; ZHANG Ai-ling; HE Yan; LUO Xiao-jian; WANG Yue-sheng; PENG Lin

doi:10.13422/j.cnki.syfjx.2014160019

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Optimization of Matrix Formulation for Fumikang Gels by Central Composite Design-response Surface Methodology

更新时间：2024-01-04

- Optimization of Matrix Formulation for Fumikang Gels by Central Composite Design-response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 16, Pages: 19-22(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014160019
  CLC： R283.6
- Published：2014
- 稿件说明：
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YE Hai-na, ZHANG Ai-ling, HE Yan, et al. Optimization of Matrix Formulation for Fumikang Gels by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(16): 19-22.
DOI：

YE Hai-na, ZHANG Ai-ling, HE Yan, et al. Optimization of Matrix Formulation for Fumikang Gels by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(16): 19-22. DOI： 10.13422/j.cnki.syfjx.2014160019.

摘要

目的：优选妇糜康凝胶剂的基质处方。方法：以黏度（32℃）、触变性（32℃）、稳定性为因变量，羧甲基纤维素钠（CMC-Na）、甘油和聚山梨酯80（tween-80）用量为自变量，通过单因素试验筛选各自变量的取值范围，通过星点设计-效应面法优选基质配方。结果：最佳基质配方为CMC-Na 3.5 g，甘油8.0 g，tween-80 5.0 g；稳定性、触变性、黏度的实测值分别为19.5分，7 686.9 Pa·s-1·mL-1，4 325.9 mPa·s，预测值依次为20分，7 815.843 Pa·s-1·mL-1，4 442.731 mPa·s，偏差绝对值分别为2.50%，1.65%，2.63%。结论：制备的妇糜康凝胶剂黏度适中、稳定性、触变性均较好，为该制剂的临床推广提供参考。

Abstract

Objective: To optimize matrix formulation of Fumikang gels. Method: With viscosity (32℃)

thixotropy (32℃) and stability as dependent variables

amounts of sodium carboxymethyl cellulosef (CMC-Na)

glycerine and polysorbate 80 (tween-80) as independent variables

single factor test was adopted to screen ranges of each independent variable

matrix formulation of Fumikang gels was optimized by central composite design-response surface methodology. Result: Optimal formulaiton was as following:CMC-Na 3.5 g

glycerine 8.0 g

tween-80 5.0 g;these measured values of stability

thixotropy and viscosity were 19.5 point

7 686.9 Pa· s-1· mL-1 and 4 325.9 mPa· s;these predicted values were 20 point

7 815.843 Pa· s-1· mL-1 and 4 442.731 mPa· s;absolute values of deviations between the measured value and the predicted value were 2.50%

1.65% and 2.63%

respectively. Conclusion: These prepared Fumikang gels had appropriate viscosity

good stability and thixotropy

this study could provide a reference for clinical practice of this preparation.

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