Objective: To optimize extraction technology of Herba Polygoni Chinensis and other Thirteen kinds of medicinal materials in Ganyou capsules. Method: With composite score of extraction amounts of polydatin and resveratrol as index

orthogonal test was adopted to optimize water extraction technology of Ganyou capsules by taking the amount of water

soaking time

extraction time and times as factors.Contents of polydatin and resveratrol were determined by HPLC

mobile phase consisted of methanol-0.5% phosphoric acid solution (35:65)

detection wavelength was set at 306 nm and flow rate was 0.9 mL· min-1. Result: Optimum extraction conditions were as follows:soaked 0.5 h with eight times the amount of water

extracted twice for 2 h per time;under these conditions

average extracting amounts of polydatin and resveratrol were 0.676

0.198 mg· g-1

RSD were 0.56% and 0.91%

respectively. Conclusion: This optimized extmction technology was stable and feasible

it would provide experimental basis for improvement of quality stability and clinical drug safety of Ganyou capsules.