Objective: To observe effects of Artemisiae Argyi Folium aqueous extract and its ferment substance on candida albicans vaginitis in mice. Method: The Candida albicans vaginitis model was induced by the vagina in mice which were vaccinated 1×107cfu/mL C. albicans suspension 20 μL. The model mice were randomly divided into control group

model group

Artemisiae Argyi Folium aqueous extract group(20 g· L-1)

Artemisiae Argyi Folium ferment substance (AAFS) groups with different doses (10

20

40 g· L-1) and fluconazole group (2 g· L-1)

15 mice each group. The mice in each group were given therapeutic drugs by vagina vaccination for 7 d

once per day. The candida albicans and epithelial cells in vaginal lavage liquid were determined by microscopic examination. HE staining observed pathological changes of vaginal tissue. Result: The candida albicans infection was found in model group

but not in blank control group. Compared with the model group

AAFS with different doses and fluconazole could remarkably increase negative-converting rate of candida albicans and epithelial cells

decrease CFU number

and reduce the damage of vaginal tissue at 5 or 8 day after the treatment (P<0.05

P<0.01)

and AAFS with middle and high doses had more remarkable effects at 8 d after administration(P<0.01)

but Artemisia Argyi aqueous extract group had no difference on above indexes. Conclusion: Compared with Artemisia Argyi aqueous extract

AAFS had significant therapeutic effects on C. albicans vaginitis in mice.