Antidepressant Activity of -butanol Extracts from  Pierre

LU Hai-xiao; WANG Qiong-qiu; LI Jia-zhou; LI Ming-zhen

doi:10.13422/j.cnki.syfjx.2014160156

您当前的位置：

首页 >

文章列表页 >

Antidepressant Activity of -butanol Extracts from Pierre

更新时间：2024-01-04

- Antidepressant Activity of -butanol Extracts from Pierre
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 16, Pages: 156-159(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014160156
  CLC： R285.5
- Published：2014
- 稿件说明：
移动端阅览
LU Hai-xiao, WANG Qiong-qiu, LI Jia-zhou, et al. Antidepressant Activity of -butanol Extracts from Pierre[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(16): 156-159.
DOI：

LU Hai-xiao, WANG Qiong-qiu, LI Jia-zhou, et al. Antidepressant Activity of -butanol Extracts from Pierre[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(16): 156-159. DOI： 10.13422/j.cnki.syfjx.2014160156.

摘要

目的：探讨二色桂木提取物的抗抑郁活性及其作用机制。方法：采用KM种小鼠（雄性）悬尾、强迫游泳和利血平诱导抑郁症模型，以ig连续给药10 d（空白组等容生理盐水；氟西汀组50 mg·kg-1；二色桂木粗提物及其石油醚、乙酸乙酯、正丁醇部位及水部位各给药组200 mg·kg-1），研究二色桂木醇提物及其不同极性部位的抗抑郁活性；采用荧光分光光度法测定海马及纹状体5-羟色胺（5-HT）。结果：二色桂木醇提物及石油醚部位、乙酸乙酯部位、正丁醇部位和水部位均可不同程度地缩短小鼠游泳和悬尾的不动时间，其中正丁醇部位的作用最显著（P<0.05或P<0.01），并能显著拮抗利血平引起的体温下降和眼睑下垂等生理变化（P<0.05或P<0.01），显著提高5-HT在海马、纹状体中的含量（P<0.05或P<0.01）。结论：二色桂木醇提物具有抗抑郁作用，其活性成分主要分布在正丁醇部位。

Abstract

Objective: To study the antidepressant activity and mechanism of extracts from Artocarpus styracifolius Pierre (AS). Method: Antidepressant activity was tested by tail suspension test

force swimming test and reserpine model of different polar extracts from AS

and serotonin (5-HT) content was determined by fluorescence spectrophotometry. AS was given by intragastric administration for 10 days (fluoxetine group 50 mg· kg-1; each AS group 200 mg· kg-1). Result: The different polar extracts of AS could shorten immobility time in tail suspension test and force swimming test on mice(P<0.05 or P<0.01). Action of n-butanol extract of AS could have an antagonistic action on reserpine caused drop of body temperature and blepharoptosis and improved 5-HT content in hippocampal convolution and corpus striatum on mice(P<0.05 or P<0.01). Conclusion: Extracts of AS had antidepressant activity

and activity part may be n-butanol extract.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of Antidepressant Quality Markers of Bupleuri Radix Before and After Vinegar-processing Based on UPLC-Q-TOF-MS and Network Pharmacology

Optimal Ratio of Rehmanniae Radix and Lilii Bulbus in Baihe Dihuangtang Based on Antidepressant Activity and Its Mechanism

Research Progress on Antidepressant Pathway and Active Ingredients of Xiaoyaosan and Its Analogous Prescriptions

Clinical Observation of Addition and Subtraction Therapy of Taohong Siwutang Combined with Chaihu Shugansan to Unstable Angina Pectoris with Type A Behavior Pattern

Serum Pharmacochemical Analysis of Periploca forrestii Rhizomes Based on UPLC-Q-TOF-MS

Related Author

GAO Xingxiao

HAO Min

LI Fuyan

SUN Peng

Mingzhu GONG

Yueyue ZHANG

Lingling SONG

Yiting WANG

Related Institution

School of Pharmacy，Shandong University of TCM

School of Pharmacy， Zhejiang Chinese Medical University

Zaozhuang Hospital，Dongfang Hospital，Beijing University of Chinese Medicine/Zaozhuang Hospital of Traditional Chinese Medicine（TCM）

College of Pharmacy，Henan University of Chinese Medicine

Shenzhen Traditional Chinese Medicine Hospital

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰