Objective: Discuss near-term and forward analgesic effect of Jiawei Shaofu Zhuyu decoction combined with moxibustion therapy and influence to hemorheology

prostaglandin E2 (PGE2)and prostaglandin 2α (PGF2α) in treating primary dysmenorrhea(PD). Method: One hundred and eight patients who had by random number table were divided into control group (53 cases) and observation group (55 cases).Period of this study was divide into introduction period(the first menstrual cycle

D1)

cure period(the second

third and fourth menstrual cycle

D2-4) and follow-up period(the fifth and sixth menstrual cycle

D5 and D6). Patients in two groups were received aspirin effervescent tablets in introduction period and cure period

0.5 g/time

3 times/day

taken orally necessarily visual analogue scale(VAS≥5 scores). In cure period

patients in control group received aspirin effervescent tablets

0.5 g/time

3 times/day

and used at the third day before menstruation and stopt at the first day after menstruation.Patients in observation group received jiawei Shaofu Zhuyu decoction(taken orally)

1 dose/day

and used at the fifth day before menstruation and stopt at the first day after menstruation.moxibustion therapy used at the third day before menstruation and stopt at the second day after menstruation.Recording the degree of dysmenorrhea score(VAS)

duration of dysmenorrhea and symptoms of dysmenorrhea from D1 to D6.Before and after treatment

hemorheology was detected.And levels of serous of PGF2 and PGE2α were detected. Result: At the point-in-time of D2

compared with the point-in-time of D1

scores of VAS

duration and symptoms of dysmenorrhea in two groups decreased(P<0.01)

and at the point-in-time of D3 and D4

there was a decreasing trending of scores of VAS

duration and symptoms of dysmenorrhea in two groups.At the point-in-time of D5 and D6

scores of VAS

duration and symptoms of dysmenorrhea in two groups increased

and which were higher than those in two groups of the point-in-time of D4(P<0.01).And at the point-in-time of D2 to D6

scores of VAS

duration and symptoms of dysmenorrhea in observation group were lower than those in control group(P<0.01).After treatment

amelioration of whole blood viscosity(low shear and high shear)

plasma viscosity

whole blood reduced viscosity

fibrinogen and hematokrit in observation group were superior to those in control group(P<0.01).And levels of PGE2 in observation group was higher than in control group

but levels of PGF2α and PGF2α/PGE2were lower than those in control group (P<0.01). Conclusion: Jiawei Shaofu Zhuyu decoction combined with moxibustion therapy had significant near-term and forward analgesic effect in treating primary dysmenorrhea

the mechanism of action may be related to improving blood circulation

adjusting prostaglandin and giving play to analgesia effect.