Optimization of Preparation Technology of Volatile Oil from Houttuyniae Herba Dropping Pills by Central Composite Design and Response Surface Methodology

LI Ying; JI Sha; NI Li-jian; ZHENG Qin-xin; LIN Shu-zhen; WANG He-ming

doi:10.13422/j.cnki.syfjx.2014170014

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Optimization of Preparation Technology of Volatile Oil from Houttuyniae Herba Dropping Pills by Central Composite Design and Response Surface Methodology

更新时间：2024-01-04

- Optimization of Preparation Technology of Volatile Oil from Houttuyniae Herba Dropping Pills by Central Composite Design and Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 17, Pages: 14-19(2014)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2014170014
  CLC： R283
- Published：2014
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LI Ying, JI Sha, NI Li-jian, et al. Optimization of Preparation Technology of Volatile Oil from Houttuyniae Herba Dropping Pills by Central Composite Design and Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 14-19.
DOI：

LI Ying, JI Sha, NI Li-jian, et al. Optimization of Preparation Technology of Volatile Oil from Houttuyniae Herba Dropping Pills by Central Composite Design and Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 14-19. DOI： 10.13422/j.cnki.syfjx.2014170014.

摘要

目的：优选鱼腥草挥发油滴丸的制备工艺。方法：采用超临界CO2萃取法提取鲜鱼腥草中挥发油。以成品的外观评分、溶散时限和甲基正壬酮含量的总评“归一值”为评价指标，在单因素试验基础上，采用四因素五水平星点试验考察滴距、基质与挥发油质量比、药液温度和冷凝液上部温度对鱼腥草挥发油滴丸制备工艺的影响，对试验数据进行多元线性、二项式方程和三项式方程拟合，建立回归模型，通过效应面法确定最佳工艺并进行预测分析和验证试验。采用GC测定甲基正壬酮含量。结果：鱼腥草挥发油滴丸的最佳制备工艺为滴管口径2 mm，滴速50 d·min-1，基质PEG 4000-PEG 6000（1：1），冷凝液为二甲基硅油，滴距6.2 cm，基质-挥发油（3.7：1），药液温度87.4 ℃，冷凝液上部温度7.9 ℃；外观评分、崩解时限、甲基正壬酮质量分数平均值分别为82分，16.4 min，1.83 μg·g-1，与预测值的偏差依次为2.04%，1.49%，1.61%。结论：星点设计-效应面法适用于鱼腥草挥发油滴丸的制备工艺优化，建立的数学模型具有良好的预测性，为鱼腥草制剂的开发提供参考。

Abstract

Objective: To optimize preparation process of volatile oil from Houttuyniae Herba dropping pills. Method: Volatile oil from Houttuyniae Herba was extracted by supercritical CO2 fluid extraction.Taking overall desirability of appearance grade

dissolve time limit and methyl-n-nonyl-ketone content as dependent variable

on the basis of single factor tests

central composite design and response surface methodology was adopted optimize preparation technology with dropping distance

proportion of matrix and volatile oil

liquid temperature and upper temperature of condenser pipe as independent variables.The content of methyl-n-nonyl-ketone was determined by GC. Result: Optimum preparation technology was as follows:dropper caliber of 2 mm

dripping speed of 50 d·min-1

matrix of PEG 4000-PEG 6000 (1:1)

dimethyl silicone oil as condensate

dropping distance of 6.8 cm

proportion of matrix-volatile oil (3.7:1)

liquid temperature at 87.4 ℃ and upper temperature of condenser pipe at 7.9 ℃;average values of appearance grade

dissolve time limit and methyl-n-nonyl-ketone content were 82 points

16.4 min and 1.83 μg·g-1

whose deviation were 2.04%

1.49% and 1.61% by comparing with these predicted values

respectively. Conclusion: Central composite design and response surface methodology was suitable for optimizing preparation process of this preparation with good predictability

this study could provide a reference for development of Houttuyniae Herba preparations.

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