LIU Ju-yan, CHAO Jian-guo, GU Wei, et al. Study on Serum Pharmacochemistry of Xiefei Pingchuanling Extract[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 110-113.
DOI:
LIU Ju-yan, CHAO Jian-guo, GU Wei, et al. Study on Serum Pharmacochemistry of Xiefei Pingchuanling Extract[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 110-113. DOI: 10.13422/j.cnki.syfjx.2014170110.
Study on Serum Pharmacochemistry of Xiefei Pingchuanling Extract
Objective: This article aimed to to study the main pharmacodynamic substances of pediatric compound preparation Xiefei Pingchuanling by serum pharmacochemistry. Method: UPLC-LTQ-Qrbitrap technology was used to create fingerprints of both compound extract and rat serum after treatment. Then the peaks were compared and predicted to belong to which single herb and their constituents were inferre. Result: 18 transitional ingredients in Xiefei Pingchuanling were detected and identified in rat serum
10 of which could be directly absorbed into the bloodstream by the body;the 8 remaining prototype components may be new ingredients produced through metabolism. Conclusion: UPLC fingerprint provides much medicinal information in plasma of rats treated with Xiefei Pingchuanling
therefore
it is of great value to studies on the metabolism of traditional Chinese medicine (TCM).
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Related Author
GUO Si-qun
ZHU Kui-yuan
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ZHANG Ning
ZHANG Sitong
HU Xianrun
LIU Wenkang
Related Institution
Key Laboratory for Standardization of Chinese Medicines,Ministry of Education, Shanghai Key Laboratory for Compound Chinese Medicines,Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine
Jiangxi University of Chinese Medicine
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
Tianjin University of Traditional Chinese Medicine