Chemical Constituents of Ethyl Acetate Fraction of Ginseng Radix et Rhizoma Medicinal Fungal Substance

GANG Wan-jiao; WANG Ming-jiao; GUAN Sheng-yuan; XU Wei

doi:10.13422/j.cnki.syfjx.2014170114

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Chemical Constituents of Ethyl Acetate Fraction of Ginseng Radix et Rhizoma Medicinal Fungal Substance

更新时间：2024-01-04

- Chemical Constituents of Ethyl Acetate Fraction of Ginseng Radix et Rhizoma Medicinal Fungal Substance
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 17, Pages: 114-116(2014)
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- DOI：10.13422/j.cnki.syfjx.2014170114
  CLC： O657.7;R284.1
- Published：2014
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GANG Wan-jiao, WANG Ming-jiao, GUAN Sheng-yuan, et al. Chemical Constituents of Ethyl Acetate Fraction of Ginseng Radix et Rhizoma Medicinal Fungal Substance[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 114-116.
DOI：

GANG Wan-jiao, WANG Ming-jiao, GUAN Sheng-yuan, et al. Chemical Constituents of Ethyl Acetate Fraction of Ginseng Radix et Rhizoma Medicinal Fungal Substance[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 114-116. DOI： 10.13422/j.cnki.syfjx.2014170114.

摘要

目的：按照优选的生物转化技术对人参进行生物转化，得到全新产物人参药性菌质，并对其乙酸乙酯部位化学成分进行研究，阐明其药效物质基础。方法：利用薄层色谱、硅胶柱色谱、Sephadex LH-20凝胶色谱、半制备液相等方法进行分离纯化，根据化合物的理化性质和波谱数据鉴定其结构。结果：分离得到6个化合物，分别为邻苯二甲酸二（2-乙基己酯）（1），邻苯二甲酸二丁酯（2），豆甾烷-5，22-二烯-3β-醇（3），β-谷甾醇（4），豆甾烷-22-烯-3，6-二酮（5），豆甾烷-3，6-二酮（6）。结论：所有化合物均为首次从人参药性菌质中分离得到。

Abstract

Objective: The Ginseng Radix et Rhizoma was biotransformed under the optimal condition to obtain the new product medicinal fungal substance of ginseng. This study was conducted to investigate the chemical constituents of the ethyl acetate fraction of medicinal fungal substance ginseng

to clarify the substance basis of efficacy. Method: Thin-layer chromatography

column chromatography on silica gel

Sephadex LH-20 gel chromatography and semi-preparative liquid chromatography were used for isolation and purification of the compounds

and their structures were determined by comparison of their chromatographic and spectral data with those of the authentic samples and those reported in the literatures. Result: Six compounds were identified as phthalate acid bis(2-ethylhexyl)ester (1)

dibutylphthalate (2)

stigmasta-5

22-dien-3-beta-ol (3)

a-sitosterol(4)

stigmast-22-ene-3

6-dione (5)

stigmasta-3

6-dione (6). Conclusion: All compounds were isolated from the medicinal fungal substance of Ginseng Radix et Rhizoma for the first time.

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