Chemical Constituents from (Ⅰ)

WANG Liu-kai; WU Shou-yuan; ZHENG Cai-juan; SONG Xiao-ping; CHEN Guang-ying; LI Xiao-bao; CHEN Xiao-hong

doi:10.13422/j.cnki.syfjx.2014170117

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Chemical Constituents from (Ⅰ)

更新时间：2024-01-04

- Chemical Constituents from (Ⅰ)
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 17, Pages: 117-120(2014)
- 作者机构：
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- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014170117
  CLC： O657.7;R284.1
- Published：2014
- 稿件说明：
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WANG Liu-kai, WU Shou-yuan, ZHENG Cai-juan, et al. Chemical Constituents from (Ⅰ)[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 117-120.
DOI：

WANG Liu-kai, WU Shou-yuan, ZHENG Cai-juan, et al. Chemical Constituents from (Ⅰ)[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 117-120. DOI： 10.13422/j.cnki.syfjx.2014170117.

摘要

目的：研究沙煲暗罗的化学成分。方法：采用95%乙醇提取，硅胶柱层析，Sephadex LH-20及重结晶等方法从沙煲暗罗茎和叶中分离化学成分，并根据光谱数据和理化性质确定各化合物的结构。结果：分离获得了8个化合物，其中生物碱类化合物为isooncodine（1），pendulamine A（2），甾体类化合物为stigmasta-4-ene-3，6-dione（3），β-谷甾醇（4），豆甾醇（5），其他化合物为对苯二酚（6），香草醛（7），十八碳二烯酸（8）。结论：所有化合物均为首次从该属植物中分离得到，抗菌活性测试结果表明，化合物3对大肠埃希菌（Escherichia coli）有抑制作用，其最小抑菌浓度（MIC）值达到 5 mg·L-1；抗肿瘤活性测试结果表明，生物碱类化合物1对小鼠黑色素瘤细胞（B16F10）和肺癌肿瘤细胞（A-549）具有一定抑制活性，半抑制率（IC50）分别为78.6，49.3 mg·L-1。

Abstract

Objective: This study was carried out to study the chemical constituents from of Polyalthia oblique. Method: Compounds from 95% ethanolic extract of P. oblique were isolated by column chromatography on silica gel

Sephadex LH-20

together with recrystallization

and their structures were identified by their physical characteristics and spectral features. Result: Eight compounds were isolated from P. oblique

and identified as alkaloids isooncodine (1)

pendulamine A (2)

three steroids stigmasta-4-ene-3

6-dione (3)

β-sitosterol (4)

stigmasterol (5)

and three other compounds including hydroquinone (6)

vanillin (7)

octadecadienoic acid (8). Conclusion: All compounds were isolated from P. oblique for the first time. Compound 3 showed inhibition activity against Escherichia coli

with minimal inhibitory concentrations(MIC) value of 5 mg·L-1. Compound 1 showed weak inhibition activities against SPC-A-1 and A-549 tumor cells

with IC50 values of 78.6

49.3 mg·L-1.

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