CHEN Chun-miao, ZHOU Jun, CHEN Jian, et al. Protective Effects of Ginkgo Terpene Lactones Meglumine Injection on Focal Cerebral Ischemia Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 133-136.
DOI:
CHEN Chun-miao, ZHOU Jun, CHEN Jian, et al. Protective Effects of Ginkgo Terpene Lactones Meglumine Injection on Focal Cerebral Ischemia Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 133-136. DOI: 10.13422/j.cnki.syfjx.2014170133.
Protective Effects of Ginkgo Terpene Lactones Meglumine Injection on Focal Cerebral Ischemia Reperfusion Injury in Rats
Objective: To investigate the protective effects of Ginkgo terpene lactones meglumine injection (GTLMI)on cerebral focal ischemia reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats. Method: Ninety six male SD rats were divided into six groups
such as sham
model
nimodipine(0.4 mg·kg-1)
and GTLMI(4.8
2.4
1.2 g·kg-1)groups. All of rats were given corresponding drugs by tail vein injection before modeling. Except the sham group
the cerebral ischemic stroke model was used. The effects of GTLMI on the brain neurological deficit score
and the brain infraction areas percentage were observed.The influence of GTLMI on the activities of superoxide dismutase (SOD)
content of malondialdehyde (MDA)
creatine kinaes BB isozyme (CK-BB) in blood serum and the activities of Caspase-3 in brain were assayed. Result: Compared with MCAO group
GTLMI could obviously reduce the infract area
increase the activities of SOD
and decrease the content of MDA
CK-BB in blood serum and Caspase-3 in brain. Conclusion: GTLMI can protect the focal cerebral ischemia reperfusion injury in rats.The mechanisms may be related to recovering the blood brain barrier
decreasing the content of CK-BB
scavenging free radicals and reduction of the expression of Caspase-3.