Effect and Mechanism of Longli Pingchuan Paste on Airway Inflammation in Asthma Rat

QIAO Yun; YI Wei

doi:10.13422/j.cnki.syfjx.2014170150

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Effect and Mechanism of Longli Pingchuan Paste on Airway Inflammation in Asthma Rat

更新时间：2024-01-04

- Effect and Mechanism of Longli Pingchuan Paste on Airway Inflammation in Asthma Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 17, Pages: 150-154(2014)
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2014170150
  CLC： R285.5
- Published：2014
- 稿件说明：
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QIAO Yun, YI Wei. Effect and Mechanism of Longli Pingchuan Paste on Airway Inflammation in Asthma Rat[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 150-154.
DOI：

QIAO Yun, YI Wei. Effect and Mechanism of Longli Pingchuan Paste on Airway Inflammation in Asthma Rat[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 150-154. DOI： 10.13422/j.cnki.syfjx.2014170150.

摘要

目的：探讨龙脷平喘膏对发作期小儿哮喘气道炎症的影响。方法：48只大鼠按体重均衡随机分为空白对照组、模型组、地塞米松组（1 mg·kg-1）、龙脷平喘膏高、中、低剂量组（74.8，37.4，18.7 g·kg-1），每组8只。采用卵清蛋白（OVA）复制哮喘大鼠模型，连续给药1周，记录大鼠过敏性鼻炎症状，取鼻黏膜和肺组织，观察鼻黏膜及肺组织病理形态变化，并检测肺组织炎症细胞凋亡率和原癌基因Fas（Fas mRNA），B细胞淋巴瘤/白血病2基因（Bcl-2 mRNA）的表达。结果：除空白组外，其他各组在引发过敏性哮喘的同时均诱发了不同程度的过敏性鼻炎症状，且模型组鼻黏膜和肺组织均见嗜酸粒细胞浸润及相似的病理形态学改变；与空白组比较，模型组大鼠搔鼻和喷嚏的次数显著增多（P<0.01）；与模型组比较，龙脷平喘膏能明显减少哮喘大鼠搔鼻和喷嚏的次数（P<0.01）。与空白组比较，模型组大鼠肺组织中炎症细胞凋亡率显著降低（P<0.01）；与模型组比较，龙脷平喘膏高、中剂量组大鼠肺组织中炎症细胞凋亡率明显升高（P<0.05），且肺组织中促炎症细胞凋亡的调控基因Fas mRNA阳性表达率显著升高（P<0.01），抑制炎症细胞凋亡的调控基因Bcl-2 mRNA阳性表达率则显著下降（P<0.01）。结论：龙脷平喘膏能明显抑制哮喘大鼠气道炎症，机制可能与其逆转Fas/Bcl-2失衡，促进炎症细胞凋亡有关。

Abstract

Objective: To investigate the effect and mechanism of Longli Pingchuan paste to episodes of pediatric asthma induced airway inflammation. Method: Forty-eight rats were randomly divided into blank group

model group

dexamethasone group(1 mg·kg-1) and Longli Pingchuan paste high

middle and low dose group (74.8

37.4

18.7 g·kg-1)

8 rats each group. Ovalbumin(OVA) was used to copy the rat model of asthma

administration lasted 1 week. The allergic symptoms rhinitis mucosa and lung tissue

pathologic morphological changes between the nasal mucosa and lung tissue of asthmatic rats were observed

and lung tissue inflammation cell apoptosis rate

the expression of proto oncogene Fas mRNA and B cell lymphoma/leukemia-2(Bcl-2) mRNA were detected. Result: In addition to the blank group

other groups showed allergic rhinitis symptoms allergic asthma

and eosnophil infiltration and similar pathologic morplological changer were seen in the nasal mucosa and lung tissue in model group;compared with blank group

the numbers of asthma rats in the model group increased significantly(P<0.01);compared with model group

Longli Pingchuan paste significantly reduced the number of asthma rats(P<0.01);compared with blank group

inflammation cell apoptosis rate was significantly lower in the model group(P<0.01);inflammation cell apoptosis rate was significantly higher than the model group(P<0.05)

positive expression rate of control gene Fas mRNA of proinflammatory cell apoptosis increased significantly(P<0.01)

positive expression rate of control gene Bcl-2 mRNA of inhibiting inflammation cell apoptosis decreased significantly(P<0.01) in lung tissue in Longli Pingchuan paste high and middle dose group. Conclusion: Longli Pingchuan paste can obviously inhibit airway inflammation in asthma rat

the mechanism may be related to promoting inflammation cell apoptosis and reversing Fas/Bvl-2 ratio imbalance.

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Related Institution

Henan Provincial Hospital of Traditional Chinese Medicine（TCM）/Second Affiliated Hospital of Henan University of TCM

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Children's Hospital of Shanghai， Children's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Putuo Hospital， Shanghai University of TCM

Yunnan University of Chinese Medicine

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