Objective: To observe hypoglycemic and hypolipidemic effects of Xiaoke capsules on type 2 diabetic rats. Method: Except eight Wistar rats were as the normal control

the rest sixty-two type 2 diabetic rats were induced by feeding with high-fat and high-suger diet and intraperitoneal injection of low-dose streptozotocin (STZ

35 mg·kg-1). According to the values of blood glucose concentration (>7.0 mmol·L-1)

the rats were randomly divided into diabetic model group

three Xiaoke capsules groups of high dose (0.4 g·kg-1)

medium dose (0.2 g·kg-1) and low dose (0.1 g·kg-1)

and positive control (glibenclamide

0.25 mg·kg-1) group. During 36 d of continuous administration

body weights of the rats were measured weekly. The values of fasting blood glucose concentration were measured on 0

8

16

24

32 d of the experiment. After the last administration

12 h latter

the rats were decapitated after anesthesia. Blood of the rats were collected for the analysis of serum insulin(INS)

total cholesterol(TC)

triglycerides(TG) and low-density lipoprotein(LDL-C) levels. Pancreas of the rats were collected for histopathological examination. Result: Compared with normal group

model group

blood glucose was significantly increased (P<0.01)

serum INS was significantly decreased (P<0.01)

TC

TG

LDL-C was significantly increased(P<0.01). Compared with model group

Xiaoke capsules showed significant hypoglycemic effect (P<0.05)

and significant difference was observed compared to diabetic model group on serum INS

TC

TG and LDL-C levels (P<0.05). Histopathological results indicated that more numbers and much more regular shape of islets and islet cells in the medium dose and high dose of treatment groups were observed with comparison to the model group

and the morphology of endocrine cells in islets were close to those of the normal group. Conclusion: Xiaoke capsules can decrease blood glucose

regulate blood lipids in type 2 diabetic rats.