LUO Chuan, ZHAO Hai-yu, BIAN Bao-lin, et al. Cinobufacini Injection for Chronic Hepatitis B:A Systematic Review[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 212-218.
DOI:
LUO Chuan, ZHAO Hai-yu, BIAN Bao-lin, et al. Cinobufacini Injection for Chronic Hepatitis B:A Systematic Review[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 212-218. DOI: 10.13422/j.cnki.syfjx.2014170212.
Cinobufacini Injection for Chronic Hepatitis B:A Systematic Review
Objective: The purpose of this study was to evaluate the efficacy and safety of cinobufacini injection on chronic hepatitis B. Method: We searched the cochrane central register of controlled trials (CCTR)
PubMed
CBM
CNKI
VIP databases up to Dec. 2012.The methodological quality assessment and data extraction of the including studies were conducted by two reviewers independently according to the inclusion and exclusion criteria. Meta-analyses were performed for homogeneous studies using RevMan 4.2.10 software. Result: A total of 17 studies involving 1 635 patients met the inclusion criteria. None of the studies enforced allocation concealment and performed blinding. Conclusion: Cinobufacini injection might be effective in normalizing alanine aminotr ansferase(ALT) levels
clearing hepatitis B virus(HBV) DNA
achieving virus seroconversion and improving hepatic fibrosis
without any serious adverse effects. However
the overall combination effect analysis could not be conducted
because the including studies were performed in small sample with low-quality. More evidence is needed to support this analysis.