Absorption Characteristics of Isochlorogenic Acid A in Rat Intestine Using Single-pass Perfusion Model

CHENG Xuan-ge; WANG Su-jun; ZENG Jie; ZHONG Yun-ming; HUANG Li-hua

doi:10.13422/j.cnki.syfjx.2014180108

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Absorption Characteristics of Isochlorogenic Acid A in Rat Intestine Using Single-pass Perfusion Model

更新时间：2024-01-04

- Absorption Characteristics of Isochlorogenic Acid A in Rat Intestine Using Single-pass Perfusion Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 18, Pages: 108-112(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014180108
  CLC： R285.5
- Published：2014
- 稿件说明：
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CHENG Xuan-ge, WANG Su-jun, ZENG Jie, et al. Absorption Characteristics of Isochlorogenic Acid A in Rat Intestine Using Single-pass Perfusion Model[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(18): 108-112.
DOI：

CHENG Xuan-ge, WANG Su-jun, ZENG Jie, et al. Absorption Characteristics of Isochlorogenic Acid A in Rat Intestine Using Single-pass Perfusion Model[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(18): 108-112. DOI： 10.13422/j.cnki.syfjx.2014180108.

摘要

目的：研究异绿原酸A在大鼠肠道吸收特性。方法：以酚红为标示物，采用大鼠在体单向肠灌流模型研究异绿原酸A 3个质量浓度组（18，58，100 mg·L-1）在大鼠的十二指肠、空肠、回肠及结肠的吸收情况。结果：异绿原酸A在低、中、高3个浓度下，在十二指肠段、空肠、回肠与结肠段的有效渗透系数（Peff）在（0.69~6.64）×10-5cm·s-1内，且随浓度增加，有上升趋势，具有显著性差异（P<0.05），在回肠的Peff显著大于其他肠段，由此可推断回肠段是异绿原酸A的最佳吸收部位。结论：异绿原酸A在考察浓度范围内，吸收无自身浓度抑制作用，以被动扩散方式吸收，有特殊的吸收窗。

Abstract

Objective: To study the absorption of isochlorogenic acid A in rat intestine. Method: The absorptions of three concentrations (18

100 mg·L-1) of isochlorogenic acid A in different intestinal segments were studied with phenol red as the marker by in situ rats single pass perfusion model. Result: Effective permeability(Peff) of duodenum

jejunum

ileum and colon in different concentration of isochlorogenic acid A was in (0.69-6.64)×10-5cm·s-1

and there was upgrade tendency between the Peff of duodenum

jejunum

ileum and colon in different concentration of isochlorogenic acid A

and it has obvious difference among each concentration. The Peff in the ileum obviously higher than that in the duodenum

jejunum and colon

namely the ileum was the best absorption section. Conclusion: The absorption of isochlorogenic acid A was not saturated in high concentration

indicating that the transport mechanisms of isochlorogenic acid A was passive diffusion

and had a special absorption window.

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