Objective: To study the antibiosis and antiphlogosiseffects of Qianlie Miniao Shuan on acute prostatitis. Method: Sixty mice were randomly divided into six groups:blank group

model group

positive group and high

middle

low dosage groups of Qianlie Miniao Shuan (0.25

0.19

0.13 g·kg-1). The model was induced by bacterial infection of Proteus(clinical isolates) or Escherichia coli (clinical isolates) in vivo by intraperitoneal injection after three days. The drugs were given for 5 days after mice infected 24 hours. The protective effect of mouse death was observed by the mouse model infected by E. coli or Bacillus proteus in vivo Qianlie Miniao Shuan dosing. The Petri dishes mixed qianlie miniao shuan solution and serum broth were made of different drug concentration(250.8

188.1

125.4

62.7

31.4 g·L-1)

each concentration was 4 Petri dishes.After added broth dilution

the Petri dishes were cultured at 37℃ for 48 h

and then we observed minimal bactericidal concentration(MBC) and minimal inhibitory concentration(MIC).The antibacterial and bactericidal effect of Qianlie Miniao Shuan on the main pathogens of acute prostatitis was observed by the antibacterial test in vitro. The anti-inflammatory effect of Qianlie Miniao Shuan was observed by the acute prostatitis model in rats infected by E. coli or B. proteus. Result: The mortality rates of the mice infected Proteus infection or E. coli given Qianlie Miniao Shuan in the three dosages groups were lower than the model group(P<0.05).The MBC of Staphylococcus aureus

Salmonella

Pseudomonas aeruginosa

E. coli

Proteus (clinical isolates)and E. coli (clinical isolates) were 62.7

125.4

250.8

188.1

250.8

188.1 g·L-1

The MIC of S. aureus

Salmonella

P. aeruginosa

E. coli

Proteus (clinical isolates)and E. coli (clinical isolates) were 31.4

62.7

188.1

125.4

188.1

125.4 g·L-1.The prostate organ coefficient of acute prostatitis model caused by Proteus or E. coli gived qianlie miniao shuan were less than the model group

the difference had statistical significance(P<0.05).The pathological results showed the tissue renewing in the three dose groups was better than that in the model group.The Qianlie Miniao Shuan could significantly reduce the inflammatory infiltration of prostate tissue in rats(P<0.05). Conclusion: Qianlie Miniao Shuan for acute prostatitis has good antibacterial and anti-inflammatory effects.