Objective: The purpose of this investigation was to study the effect of postoperative application of Brucea Javanica oil injection adjuvant chemotherapy on treating gastric cancer. Method: One hundred and eight patients with advanced gastric cancer were divided into observation group and control group. The control group was given XELOX adjuvant chemotherapy (oral capecitabine plus oxaliplatin into intravenous drip)

while the observation group was given auxiliary Brucea Javanica oil injection besides XELOX chemotherapy (oral capecitabine plus oxaliplatin into intravenous drip+Brucea Javanica oil injection intravenous drip). The long-term prognosis

adverse reactions

overall life quality and immune function were compared. Result: Complete response(CR)(8.62%)

efficiency(58.62%)

benefit rate(79.31%)

karnofsky(KPS) score(84.37±8.21)

QLQ-C30 score(81.84±8.34)

CD3+

CD4+

CD8+

CD4+/CD8+

natural killer(NK)(9.31±1.34)%

tumor necrosis factor(TNF-α) (1.53±0.21) ng·L-1 of observation group were higher than control group

while local recurrence(10.34%)

distant metastasis(10.34%)

nausea and vomiting(10.34%)

neurotoxicity(22.41%)

liver function damage(10.34%)

renal function damage (12.07%) were lower than control group. Conclusion: Postoperative application of Brucea Javanica oil injection adjuvant chemotherapy has positive therapeutic value for it can improve the prognosis and reduce the adverse reaction.