Observation of Clinical Effects on COX-2, Ki-67 Expression in CAG Patients by Acupuncture Point Injection with Weiwei Tongtiao Tang

ZHAN Ya-mei; YOU Shao-wei; ZHAO Qi; HE Xian-ping

doi:10.13422/j.cnki.syfjx.2014180184

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Observation of Clinical Effects on COX-2, Ki-67 Expression in CAG Patients by Acupuncture Point Injection with Weiwei Tongtiao Tang

更新时间：2024-01-04

- Observation of Clinical Effects on COX-2, Ki-67 Expression in CAG Patients by Acupuncture Point Injection with Weiwei Tongtiao Tang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 18, Pages: 184-187(2014)
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- DOI：10.13422/j.cnki.syfjx.2014180184
  CLC： R259
- Published：2014
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ZHAN Ya-mei, YOU Shao-wei, ZHAO Qi, et al. Observation of Clinical Effects on COX-2, Ki-67 Expression in CAG Patients by Acupuncture Point Injection with Weiwei Tongtiao Tang[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(18): 184-187.
DOI：

ZHAN Ya-mei, YOU Shao-wei, ZHAO Qi, et al. Observation of Clinical Effects on COX-2, Ki-67 Expression in CAG Patients by Acupuncture Point Injection with Weiwei Tongtiao Tang[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(18): 184-187. DOI： 10.13422/j.cnki.syfjx.2014180184.

摘要

目的：探讨贵州草药组方的萎胃通调汤内服合复方当归注射液穴位注射对慢性萎缩性胃炎（CAG）治疗的临床疗效。方法：将符合诊断标准的120例患者，随机分为中药组（萎胃通调汤组）、穴位组、中药加穴位组（萎胃通调汤加穴位注射组）、胃复春对照组4组，分别治疗3个月。观察4组患者治疗前后临床症状积分、病理情况以及环氧合酶-2（COX-2），兔抗人增殖细胞核抗原单克隆抗体（Ki-67）积分的变化情况。结果：治疗组中药加穴位组临床症状较其他3组有明显改善（P <0.05），病理改变也优于其他3组（P<0.05），其中胃黏膜肠上皮化生与萎缩的变化具有显著性差异（P<0.05）；4组治疗前后COX-2，Ki-67的蛋白表达积分也有明显的变化（P<0.05）。结论：萎胃通调汤内服合复方当归注射液穴位注射对CAG的临床症状、病理变化、COX-2，Ki-67的蛋白表达积分有明显的改善作用。

Abstract

Objective: The purpose of this paper is to observe the clinical effect of taking Weiwei Tongtiao tang-a prescription from herbal medicine in Guizhou province and combining with injection into acupuncture point on treating chronic atrophic gastritis(CAG). Method: Randomly 120 cases which meet the diagnostic criteria were divided into 4 groups to cureby 4 different methods

the 1st method was only to take Weiwei Tongtiao tang (n=30)

the 2nd was only to choose acupuncture point injection (n=30)

the 3rd was to combine taking Weiwei Tongtiao tang and injection into acupuncture point(n=30)

while the 4th was only to take Weifuchun tablet (n=30). After 3 months treatment

the score changes of clinical symptom and pathological signs before and treatment were compared. Result: We discovered that there was obvious improvement in the 3rd group comparing to others (P<0.05)

and the expression of cyclooxygenase-2(COX-2) and Ki-67 of each group also improved evidently (P<0.05). Conclusion: It was suggested that Weiwei Tongtiao tang combining with acupuncture injection can obviously improve clinical symptom of CAG.

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