Objective: Short-term and long-term effects of modified Hewei Jiangni decoction in treating Gastro-esophageal reflux disease(GERD)(stagnancy heat of the liver and stomach type) and to quality of lives were investigated. Method: One hundred and twenty-eight patients with GERD were randomly divided into western medicine groupand observation group (64 cases

respectively). Patients in western medicine group received Omeprazole Magnesium enteric-coated tablets

20 mg each time

taken at the morning and evening. Mosapride citrate tablets

5 mg each time

three times per day. Patients in observation group received Omeprazole Magnesium enteric-coated tablets and the dose was same as which in western medicine group

and also received treatment of modified Hewei Jiangni decoction

1 dose per day. Course of treatment in both groups was 8 weeks. Scores of symptoms of stagnancy heat of the liver and stomach

endoscopic of esophageal mucosa

reflux diagnostic questionnaire(RDQ) and life quality were evaluated before and after treatment. Recovered patients received a 6-moth follow-up

recurrence rates and scores of endoscopic of esophageal mucosa were graded. Result: The total effective rate of improvement of traditional Chinese medicine syndrome in observation group was 93.75%

which is superior to that in western medicine group(81.25%)(P<0.05). The total effective rate of elimination of inflammation in observation group was 90.62%

which is superior to that in western medicine group(75%)(P<0.05). Scores symptoms of stagnancy heat of the liver and stomach

endoscopic of esophageal mucosa and RDQ in observation group were all lower than those in western medicine group (P<0.01). Except for score of physical pain

the SF36 scores of health scale in observation group were higher than those in western medicine group (P<0.01). During the 6-mouth follow-up

recurrence rate in observation group was 23.5%

which is lower than that in western medicine group(64%)

and when it relapse

score of endoscopic of esophageal mucosa in observation group was lower than that in western medicine group(P<0.01). Conclusion: Based on the treatment of proton pump inhibitor

treatment of modified Hewei Jiangni decoction not only relieve short-term symptoms of GERD(stagnancy heat of the liver and stomach type)

but also improve cure rate and quality of lives

furthermore reduce long-term recurrence rate.