LI Si-yang, KONG Qing-xin, WANG Yang. Preparation and Release of CZ48 Sustained-release Nanoparticles[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 5-7.
DOI:
LI Si-yang, KONG Qing-xin, WANG Yang. Preparation and Release of CZ48 Sustained-release Nanoparticles[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 5-7. DOI: 10.13422/j.cnki.syfjx.2014190005.
Preparation and Release of CZ48 Sustained-release Nanoparticles
Objective: To prepare CZ48 sustained-release nanoparticles and investigate its in vitro release. Method: Using polylactic acid(PLA) as material
CZ48 sustained-release nanoparticles was prepared through W/O/W double emulsion technique
its micromorphology was observed by transmission electron microscope
particle size was determined by particle size analyzer and in vitro release was investigated. Result: CZ48 sustained-release nanoparticles showed obvious spherical structure with particle size of (260.6±3.2)nm
encapsulation efficiency of (88.7±2.55)% and drug-loading of (11.8±1.29)%
in vitro release studies showed that 85% of CZ48 was released from sustained-release nanoparticles in the first 48 h. Conclusion: These prepared CZ48 sustained-release nanoparticles are successfully prepared through W/O/W double emulsion technique with satisfactory encapsulation efficiency and drug-loading and obvious sustained-release
which provides data support for further research on pharmacokinetic.