Investigation of  Release and Mucosal Permeability of Linarin in Chrysanthemi Indici Flos Total Flavonoids Bioadhesive Bilayer Sustained-release Patches

DUAN Xiao-ying; MA Qiu-ying; YAN Yan-cang; CHENG Yuan-fang; ZHAI Hai-rong

doi:10.13422/j.cnki.syfjx.2014190022

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Investigation of Release and Mucosal Permeability of Linarin in Chrysanthemi Indici Flos Total Flavonoids Bioadhesive Bilayer Sustained-release Patches

更新时间：2024-01-04

- Investigation of Release and Mucosal Permeability of Linarin in Chrysanthemi Indici Flos Total Flavonoids Bioadhesive Bilayer Sustained-release Patches
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 19, Pages: 22-24(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014190022
  CLC： R283
- Published：2014
- 稿件说明：
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DUAN Xiao-ying, MA Qiu-ying, YAN Yan-cang, et al. Investigation of Release and Mucosal Permeability of Linarin in Chrysanthemi Indici Flos Total Flavonoids Bioadhesive Bilayer Sustained-release Patches[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 22-24.
DOI：

DUAN Xiao-ying, MA Qiu-ying, YAN Yan-cang, et al. Investigation of Release and Mucosal Permeability of Linarin in Chrysanthemi Indici Flos Total Flavonoids Bioadhesive Bilayer Sustained-release Patches[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 22-24. DOI： 10.13422/j.cnki.syfjx.2014190022.

摘要

目的：考察野菊花总黄酮生物黏附双层缓释贴片中蒙花苷的体外释放规律与体外透膜机制。方法：选择蒙花苷为指标成分，考察野菊花总黄酮生物黏附双层缓释贴片的体外释放规律；采用牛蛙的腹皮，通过透皮扩散试验探索药物的透膜机制。结果：体外释放和黏膜渗透的拟合方程分别为lnQ=1.387lnt-0.461（r=0.990），lnQ=0.969lnt+3.240（r=0.994 3），均符合Ritger-Peppas方程，该制剂在释放介质中释药体系为Fick扩散和凝胶骨架溶蚀的协同作用。结论：该缓释贴片的释药性较好且具有一定黏膜透过性。

Abstract

Objective: To investigate in vitro release law and mucosal permeability mechanism of linarin in Chrysanthemi Indici Flos total flavonoids bioadhesive bilayer sustained-release patches. Method: Taking linarin as index components

in vitro release law of total flavonoids bioadhesive bilayer sustained-release patches was investigated;abdominal skin of bullfrog was adopted

mucosal permeability mechanism of this preparation was explored through transdermal diffusion test. Result: Equations of in vitro release and transdermal diffusion were fitted lnQ=1.387lnt-0.461(r=0.990) and lnQ=0.969lnt+3.240(r=0.994 3)

which were in line with Ritger-Peppas equation.Release system of this preparation in release medium was synergy results of Fick diffusion and gel matrix erosion. Conclusion: These prepared patches have good sustained-release and a certain mucosal permeability.

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Related Institution

Department of Preparation Laboratory,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine

Henan University of Traditional Chinese Medicine

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