Curative Effect of Water Extract from Siraitiae Fructus on Acute Pharyngitis Model Rats

LIU Yan; LIU Zhi-yang

doi:10.13422/j.cnki.syfjx.2014190159

您当前的位置：

首页 >

文章列表页 >

Curative Effect of Water Extract from Siraitiae Fructus on Acute Pharyngitis Model Rats

更新时间：2024-01-04

- Curative Effect of Water Extract from Siraitiae Fructus on Acute Pharyngitis Model Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 19, Pages: 159-162(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014190159
  CLC： R285.5
- Published：2014
- 稿件说明：
移动端阅览
LIU Yan, LIU Zhi-yang. Curative Effect of Water Extract from Siraitiae Fructus on Acute Pharyngitis Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 159-162.
DOI：

LIU Yan, LIU Zhi-yang. Curative Effect of Water Extract from Siraitiae Fructus on Acute Pharyngitis Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 159-162. DOI： 10.13422/j.cnki.syfjx.2014190159.

摘要

目的：探讨罗汉果水提液对大鼠实验性急性咽炎动物模型的疗效及作用机制。方法：采用氨水连续3 d对大鼠咽部喷雾法建立急性咽炎动物模型，模型成功后，随机分为空白组，地塞米松对照2 mg·kg-1组，罗汉果水提液0.5，1.5，4.5 g·kg-1治疗组，连续灌胃给药5 d，观察药液对模型动物病理形态、白细胞常规计数和血清中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）表达的影响。结果：与模型组相比罗汉果水提液中、高剂量能不同程度改善急性咽炎的病理变化（P<0.01），白细胞计数结果（P<0.05，P<0.01），同时对模型动物血清中的IL-1β（P<0.05，P<0.01），IL-6（P<0.01）和TNF-α（P<0.01）的表达有明显的抑制作用。结论：罗汉果水提液对急性咽炎有较好的治疗作用，其作用机制可能与抑制咽部病理改变和调节细胞因子的表达有关。

Abstract

Objective: To study the curative effect and mechanism of the water extract from Siraitiae Fructus on acute pharyngitis model rats. Method: For 5 consecutive days

the ammonia saray was used to establish the animal model of acute pharyngitis. the modeling rats were randomly divided into blank group

dexamethasone group

the water extract of Siraitiae Fructus groups (0.5

1.5

4.5 g·kg-1)

and lavage administration for 5 days.The pharyngeal pathological changed

white blood cell count (WBC) and the expression of interleukin (IL)-1β

IL-6 and tumor necrosis factor alpha(TNF )-α in serum were observed. Result: The middle and high dose of the water extract of Siraitiae Fructus could improve the pathological changes (P<0.01) and WBC (P<0.05

P<0.01). It had obvious inhibitory effect on the expression of IL-1β(P<0.05

P<0.01)

IL-6 (P<0.01) and TNF-α (P<0.01) in serum. Conclusion: The water extract of Siraitiae Fructus has good treatment effect on the acute pharyngitis

its mechanism may be related to inhibition of pharyngeal pathological changes and the expression of inflammatory cytokine.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of Animal Models with Combined Allergic Rhinitis and Asthma Syndrome in Children Based on Clinical Disease-syndrome Characteristics of Traditional Chinese and Western Medicine

Establishment and Evaluation of Rat Model of Myocardial Ischemia-reperfusion Injury with Phlegm and Blood Stasis Blocking Collaterals Syndrome Based on Metabolomics

Establishment and Evaluation of Rat Model of Acute Myocardial Infarction in Coronary Heart Disease with Qi and Yin Deficiency Syndrome Based on Sleep Deprivation Combined with Coronary Artery Ligation

Analysis of Animal Model of Chronic Heart Failure Based on Combination of Diseases and Syndromes of Traditional Chinese Medicine and Western Medicine

Evaluation of Animal Models with Diminished Ovarian Reserve Based on Clinical Disease and Syndrome Characteristics of Traditional Chinese Medicine and Western Medicine

Related Author

CHEN Yuhang

ZHANG Ye

CHEN Hong

ZHANG Ziwei

WU Liqun

HUO Jingwei

HU Longxiao

GAO Jiabei

Related Institution

Dongfang Hospital， Beijing University of Chinese Medicine

Yunnan Provincial Hospital of Traditional Chinese Medicine

School of Clinical Medicine，Beijing University of Chinese Medicine

Beijing Key Laboratory of Chinese Materia Pharmacology，National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

Natural History Museum of China

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰