Objective: The aim of this article was to study the effect of Fufang Xueshuantong on albumin-creatinine ratio(ACR)

liver function and lipid metabolism of patients with early-stage diabetic nephropathy. Method: Patients with early stage diabetic nephropathy in our hospital from 2011 June to 2013 July were enrolled and given support treatment and hypoglycemic therapy. Then patients were divided into observation group given enalapril combined with fufangxueshuantong and control group only given enalapril. ACR

blood urea nitrogen (BUN)

creatinine clearance rate (CCr)

aspertate aminotransferase (AST) and alanine aminotransferase (ALT)

triglycerides (TG)

cholesterol (TC)

low density lipoprotein (LDL)

high-density lipoprotein (HDL) between two groups were compared. Result: In observation group

the ACR

urine protein

BUN

CCr

ALT

AST

TC

TG

LDL (4.5±2.4)mg·g-1

(0.12±0.06)mg/24 h

(5.8±1.4)mmol·L-1

(86.4± 15.6)μmol·L-1

(37.8±7.2)

(56.4±7.5)U·L-1

(2.9±0.3)

(1.1±0.2)

(2.1±0.3)mmol·L-1 were significantly lower than control group(6.6±2.3)mg·g-1

(0.19±0.07)mg/24 h

(6.5±1.3)mmol·L-1

(97.8±22.3)μmol·L-1

(53.5±10.9)

(50.9±7.4)U·L-1

(5.7±0.7)

(1.8±0.3)

(3.8±0.5)mmol·L-1;HDL(1.3±0.2)mmol·L-1was significantly higher than control group(0.7±0.1)mmol·L-1 (P<0.05 or P<0.01). Conclusion: Fufang Xueshuantong is an ideal therapy in treating early-stage diabetic nephropathy for it can improve renal function

liver function and lipid metabolism.