Objective: To investigate the effect of the extract of ginkgo biloba leaves injection (EGBLI) on microcirculation and hemorheology in patients with lung cancer undergoing chemotherapy. Method: One hundred patients with lung cancer undergoing chemotherapy were divided into EGBLI group and heparin sodium injection (HIS) group of 50 patients each by a stratified random sampling method

and 25 healthy subjects were assigned to a healthy control group. Patients with lung cancer received first-line chemotherapy. Patients in HIS group received 70-80 units/kg/day heparin sodium injection (iv drip

twice daily). Patients in EGBLI group received 20 mL extract of ginkgo biloba leaves injection (iv drip

once daily). The patients received two 10-day periods of treatment separated by 2 days without treatment. Plasma fibrinogen (Fib)

D-dimer (D-D)

platelets (PLT) and maximum platelet aggregation rate (MPAR) and hemodynamic indexes were detected before and after treatment. Result: The levels of Fib

D-D and PLT in lung cancer patients were obviously higher than those in healthy subjects (P<0.01). The levels of Fib

D-D

MPV and MPAR after treatment in EGBLI group were lower than those in HIS group (P<0.01). The better improvement of blood viscosity (high shear

low shear)

whole blood reductive viscosity (high shear

low shear)

plasma viscosity

hematokrit and erythrocyte sedimentation rate were found in EGBLI group as comparied with in HIS group (P<0.01). No significant impact on effective rate of gender and pathological factors were found. Significant higer clinical effective rate were found in patients with tumor metastasis than that with no umor metastasis (P<0.05). The cumulative adverse reactions rate in EGBLI group was 12%

which was lower than 40% in HIS group (P<0.01). Conclusion: There was significant improvement of hypercoagulable state in lung cancer patients by extract of ginkgo biloba leaves injection. Besides

it is better and safe for lung cancer patient with no tumor metastatic.