Influence of Fuzheng Huadu Decoction on Hypercoagulable State in Diabetic Nephropathy Patients Undergoing Maintenance Hemodialysis

SHI Chun-zhen; WANG Shui-hua

doi:10.13422/j.cnki.syfjx.2014190206

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Influence of Fuzheng Huadu Decoction on Hypercoagulable State in Diabetic Nephropathy Patients Undergoing Maintenance Hemodialysis

更新时间：2024-01-04

- Influence of Fuzheng Huadu Decoction on Hypercoagulable State in Diabetic Nephropathy Patients Undergoing Maintenance Hemodialysis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 19, Pages: 206-209(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014190206
  CLC： R259
- Published：2014
- 稿件说明：
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SHI Chun-zhen, WANG Shui-hua. Influence of Fuzheng Huadu Decoction on Hypercoagulable State in Diabetic Nephropathy Patients Undergoing Maintenance Hemodialysis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 206-209.
DOI：

SHI Chun-zhen, WANG Shui-hua. Influence of Fuzheng Huadu Decoction on Hypercoagulable State in Diabetic Nephropathy Patients Undergoing Maintenance Hemodialysis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 206-209. DOI： 10.13422/j.cnki.syfjx.2014190206.

摘要

目的：通过扶正化毒方对糖尿病肾病（DKD）维持透析患者凝血因子、血小板活性、血脂及血液流变学的作用，探讨其对血液高凝状态的影响。方法：将96例DKD尿毒症期患者随机按数字表法分为对照组和实验组各48例。两组给予常规对症等基础治疗，对照组口服尿毒清颗粒，5 g/次，4次/d。实验组口服扶正化毒方，1剂/d。两组疗程均为4个月。检测治疗前后纤维蛋白原（FIB）、血小板聚集率（MPAR）、D-二聚体（D-D）、血管性假性血友病因子（vWF）、血栓素（TXB2）、6-酮-前列腺素F1a（6-Keto-PGF1a）、血小板α-膜颗粒蛋白（GMP-140）水平。检测治疗前后血液流变学指标和胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平。结果：治疗后实验组6-Keto-PGF1a水平高于对照组，TXB2，MPAR及GMP-140水平低于对照组（P<0.01）；治疗后实验组D-D，FIB和vWF水平低于对照组（P<0.01）；治疗后实验组全血黏度（高切、低切）、血浆黏度、红细胞压积和血沉的改善优于对照组（P<0.01）；治疗后实验组TC，TG，LDL-C水平低于对照组，实验组HDL-C水平高于对照组（P<0.01）。结论：扶正化毒方能降低DKD尿毒症期维持血液透析患者促凝血因子水平，抑制血小板活性，调节脂代谢，改善微循环，从而改善患者血液高状态，有利于防止血栓的形成。

Abstract

Objective: To discuss the influence of Fuzheng Huadu decoction on hypercoagulable state by assessing blood coagulation factor

platelet activity

blood fat and hemorheology in patients with diabetic kidney disease(DKD) undergoing maintenance hemodialysis. Method: Ninety-six patients with DKD and uremic were randomly divided into control group and observation group of 48 patients each. All patients received basic therapy of conventional and supportive treatment. Patients in control group took oral 5 g Niaodu Qing granules 4 times daily. Patients in observation group took oral Fuzheng Huadu decoction 1 dose daily. All patients in two groups received one 4 month periods of treatment. The levels of fibrinogen(FIB)

maximum aggregation rate (MPAR)

D-dimer (D-D)

von willebrand factor (vWF)

thromboxane B2 (TXB2)

6-Ketone-prostaglandin F1a (6-Keto-PGF1a) and platelet α-glair of membrane particle (GMP-140) were detected. Also

hemorheology indexes and levels of total cholesterol (TC)

triglyceride (TG)

high-density lipoprotein cholesterol (HDL-C)

low-density lipoprotein cholesterol(LDL-C) were detected before and after treatment.Result: After treatment

the level of 6-keto-PGF1a in observation group was higher than that in control group

and levels of TXB2

MPAR and GMP-140 were lower than those in control group (P<0.01). The levels of D-D

FIB and vWF were lower than those in control group (P<0.01). Ameliorate of whole blood viscosity (high and low shear)

plasma viscosity

hematokrit and erythrocyte sedimentation rate were superior to those in control group (P<0.01). The levels of TC

TG and LDL-C in observation group were lower

and the level of HDL-C was higher than in control group (P<0.01). Conclusion: Fuzheng Huadu decoction can improve hypercoagulable state in patients with DKD undergoing maintenance hemodialysis. This effect is likely mediated by reducing promote clotting factor

inhibiting platelet activity

regulating lipid metabolism

preventing thrombus formation and improving microcirculation in patients.

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