A Meta-analysis of Randomized Controlled Trials on Xipayi Mouth Rinse for Simple Gingivitis

SUN Hong-yan; LV An-kun

doi:10.13422/j.cnki.syfjx.2014190217

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A Meta-analysis of Randomized Controlled Trials on Xipayi Mouth Rinse for Simple Gingivitis

更新时间：2024-01-04

- A Meta-analysis of Randomized Controlled Trials on Xipayi Mouth Rinse for Simple Gingivitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 19, Pages: 217-220(2014)
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2014190217
  CLC： R781.4
- Published：2014
- 稿件说明：
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SUN Hong-yan, LV An-kun. A Meta-analysis of Randomized Controlled Trials on Xipayi Mouth Rinse for Simple Gingivitis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 217-220.
DOI：

SUN Hong-yan, LV An-kun. A Meta-analysis of Randomized Controlled Trials on Xipayi Mouth Rinse for Simple Gingivitis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 217-220. DOI： 10.13422/j.cnki.syfjx.2014190217.

摘要

目的：系统评价西帕依固龈液治疗单纯性牙龈炎的临床疗效。方法：计算机检索CNKI中国知网（总库）（1979—2012）、维普期刊资源整合服务平台（1989—2013）、美国图书馆PubMed/MEDLINE相关文献。根据Jadad量表对纳入文献进行质量评价。采用Cochrane协作网提供的RevMan 5.2.0分析软件进行Meta分析。结果：共纳入6项临床随机对照研究，共490例单纯性牙龈炎患者。Meta分析结果显示，西帕依固龈液与安慰剂比较治疗单纯性牙龈炎龈沟出血指数（sulcus bleeding index，SBI）[WMD=-0.59，95%CI（-0.76，-0.42）]、菌斑指数（plaque index，PLI）[MD=-0.67，95%CI（-1.03，-0.30）]；西帕依固龈液与西药比较治疗单纯性牙龈炎SBI[MD=-0.02，95%CI（-0.14，0.10）]，PLI[MD=0.03，95%CI（-0.24，0.30）]。结论：西帕依固龈液治疗单纯性牙龈炎疗效优于安慰剂，与西药作用相似，可降低龈沟出血指数及菌斑指数，且无明显副作用，服用方便。由于纳入研究样本量小且质量较低，尚需开展高质量、多中心、大样本的临床随机双盲对照试验加以证实。

Abstract

Objective: The aim of the study was to evaluate the effectiveness of Xipayi Mouth Rinse in the treatment of simple gingivitis. Method: We systemically searched China National Knowledge Infrastructure (CNKI)(1979—2012)

Weipu Database for Chinese Technical Periodicals (1989—2013)

PubMed and Cochrane Library.The methodological quality of the included trials was assessed based on the Jadad scale and the available data were analyzed with RevMan software (version 5.2.0). Result: A total of 6 studies involving 490 participants satisfied the minimum criteria for Meta-analysis.The evidence showed that the Xipayi Mouth Rinse was compared with placebo for treatment of simple gingivitis sulcus bleeding index(SBI)[WMD=-0.59

95%CI(-0.76

-0.42)]

plaque index(PLI)[WMD=-0.67

95%CI(-1.03

-0.30)];the Xipayi Mouth Rinse was compared with western medicine for treatment of simple gingivitis [WMD=-0.02

95%CI(-0.14

0.10)]

PLI[WMD=0.03

95%CI(-0.24

0.30)]. Conclusion: The current clinical evidence showed that the effectiveness of Xipayi Mouth Rinse in the treatment of simple gingivitis higher than the Placebo

similar effects with western medicine. Bedides

it can reduce the sulcus bleeding index and plaque index with no significant side effects

and it is easy to take. However

due to the low quality studies and small sample

it is still need to be confirmed by the high-quality

multi-center

large sample

randomized

double-blind clinical controlled trials.

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