Objective: To investigate feasibility of dynamic optimization extraction method (DOEM) in extraction process of Gastrodiae Rhizoma. Method: Extraction amounts of gastrodin and parishin were regarded as indexes

based on single factor test

orthogonal design was adopted to optimize extraction process of Gastrodiae Rhizoma with solvent amount

extracting time and times as factors.Based on orthogonal design

DOEM was employed to optimize extraction condition

then extraction effects of these two processes were compared by concents of marker components

extract yield and similarity evaluation of fingerprint. Result: Optimum extraction process of orthogonal design was as follows:extracting for thrice with 8-folds of 50% ethanol

2 hours each time;contents of gastrodin and parishin were 0.50 mg·g-1 and 1.44 mg·g-1.Extraction technology of DOEM was as follows:extracting for 3 times with 8-folds of 50% ethanol

extracting time of 80

40

20 minutes;contents of gastrodin and parishin were 0.43 mg·g-1 and 1.37 mg·g-1.Relative deviations of marker components concents and total solids yield in these two processes were less than 2% with a 100% of similarity in fingerprint

indicating basic coincidence between extracts by these two processes.DOEM could save 67% of extraction time and 62% of power consumption. Conclusion: Extracts of these two methods are no difference

DOEM can significantly reduce extraction time and production costs

which means it is worth spreading in traditional Chinese medicine industry.