Objective: To investigate the effects and its mechanismof Xiebai San on allergic asthma. Method: Sixty BALB/c were divide into six groups:normal group

model groups

Xiebai San high dose(12 g·kg-1)

middle dose(6 g·kg-1)

low dose(3 g·kg-1)

dexamethasone positive group [(2 mg·kg-1)

groups mice (except those in the normal group) were sensitized with 0.2 mL sensitized solution(0.2 mL sensitized solution contains 0.1 mg OVA and 0.02 mg Al(OH)3)].Fifteen day after modeling

and corresponding drugs were given

30 min later

mice were stimulated with 5% OVA. Blood simples were collectesd for counting numbers of eosinophilic granulocyte(EOS)

and bronchoalveolar laverge fluid(BALF)was used for counting inflammatory cells.ELISA was used to assay interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) levels

Western blotting was Use to detect GATA3 and T-bet. Result: The middle dose of Xiebai San could obviously reduce numbers of EOS in the blood (P<0.01)

high dose and low dose of Xiebai San could also reduce numbers of EOS(P<0.05)

high and middle dose of Xiebai San could obviously reduce numbers of EOS in the BALF(P<0.01)

low dose Xiebai San could also reduce numbers of EOS(P<0.05)

and Xiebai San obviously reduced IL-6 and TNF-α

and GATA3

and increased T-bet. Conclusion: Xiebai San can inhibit allergic aasthma.