SHI Ya-jun, LIU Jian-yun, YANG Ming. Evaluation of Dissolution and Oxidation Resistance of Different Extracts Obtained from Scutellariae Radix[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 1-4.
DOI:
SHI Ya-jun, LIU Jian-yun, YANG Ming. Evaluation of Dissolution and Oxidation Resistance of Different Extracts Obtained from Scutellariae Radix[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 1-4. DOI: 10.13422/j.cnki.syfjx.2014210001.
Evaluation of Dissolution and Oxidation Resistance of Different Extracts Obtained from Scutellariae Radix
Objective: To determine dissolution of different extracts of Scutellariae Radix and investigate its oxidation resistance. Method: According to pre-treatment process to collect extracts of Scutellariae Radix containing different associated substances(The content of baicalin were 19.75%
62.83%
84.55% and 98.0%)
HPLC was employed to determine dissolution of baicalin in each sample with mobile phase of methanol-water-phosphoric acid(47:53:0.2) and detection wavelength at 280 nm.Antioxidant capacity of different extracts of Scutellariae Radix was measured by DPPH
detection wavelength was set at 516 nm. Result: The higher baicalin content in different associated substances
the lower bioavailability;cumulative dissolution rates of these four extracts in 3 h were 38.24%
25.91%
23.49% and 22.98%.With increasing the content of baicalin in extracts
antioxidant capacity increased
there were no obvious changes in antioxidant capacity when the content of baicalin reached above 85%. Conclusion: Different quality and quantity of associated substances have a certain effect on dissolution and oxidation resistance of baicalin.
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