DENG Xin-huan, WANG Ya-jing, YU Yue, et al. Investigation of Transdermal Properties of Bakuchiol-baicalin Compound Microemulsions[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 5-8.
DOI:
DENG Xin-huan, WANG Ya-jing, YU Yue, et al. Investigation of Transdermal Properties of Bakuchiol-baicalin Compound Microemulsions[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 5-8. DOI: 10.13422/j.cnki.syfjx.2014210005.
Investigation of Transdermal Properties of Bakuchiol-baicalin Compound Microemulsions
Objective: To prepare bakuchiol-baicalin compound microemulsions and investigate its in vitro transdermal diffusion characteristics. Method: With ethyl oleate as oil phase
tween-80 as emulsifier and polyethylene glycol-400(PEG-400) as co-emulsifier
aqueous phase was gradually added into mixture containing drug to produce bakuchiol-baicalin compound microemulsions.Morphology
particle size distribution and stability were characterized.Transdermal characteristics of bakuchiol and baicalin in solution and microemulsions were studied by modified Franze diffusion cell. Result: Clear and transparent microemulsion were prepared
they were showed nearly spherical under transmission electron microscope
particle size was (17.30±0.17)nm with excellent stability.Cumulative permeation amounts of baicalin in solution and microemulsions were (208.80±5.26)μg·cm-2 and (232.38±15.07)μg·cm-2 in 24 h
there were no significant difference of their transdermal characteristics.Cumulative permeation amounts of bakuchiol in solution and microemulsions were (324.81±56.63)μg·cm-2 and (721.30±108.88)μg·cm-2 in 24 h
compared with steady-state infiltration rate and apparent permeability coefficient in solution
these two parameters 5.0 times significantly improved. Conclusion: Delivery system of microemulsions can significantly improve percutaneous absorption.This study provides experimental foundations for development of a new preparation of bakuchiol-baicalin compound skin delivery system.
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