Objective: To study the rapid detection of phenolphthalein content adulterated to Chinese pattern diet drugs by Raman Spectroscopy. Method: In this paper

4 portions of Chinese pattern diet drugs were extracted by 5 mL of methanol

sonicated for 10 min

then filtered and tested directly by raman spectroscopy. Result: Calibration curve was defined and analysis was performed on samples with different contents of Phenolphthalein. Results were in accordance with real amount of adulteration. The concentration of phenolphthalein and the intensity of its raman signal was in good linear at the concentration above 0.1% (r=0.998 1

RSD 3.7%). Conclusion: Samples adulterated with phenolphthalein

pretreated by a suitable method could be fast screened by raman spectroscopy. This method is fast

simple and low-cost with the detection limit at 1% for phenolphthalein. Either qualitative or quantitative results can be obtained simultaneously.