Determination of Monoester-alkaloids from Aconiti Kusnezoffii Radix Cocta in Xiaojin Wan

REN Gui-lin; HAN Li; WANG Xiao-ping; MEI Ming; HE Jing; TANG Yi-xuan; ZHANG Ding-kun; YANG Ming

doi:10.13422/j.cnki.syfjx.2014210123

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Determination of Monoester-alkaloids from Aconiti Kusnezoffii Radix Cocta in Xiaojin Wan

更新时间：2024-01-04

- Determination of Monoester-alkaloids from Aconiti Kusnezoffii Radix Cocta in Xiaojin Wan
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 21, Pages: 123-126(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014210123
  CLC： R283.6;R284.1
- Published：2014
- 稿件说明：
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REN Gui-lin, HAN Li, WANG Xiao-ping, et al. Determination of Monoester-alkaloids from Aconiti Kusnezoffii Radix Cocta in Xiaojin Wan[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 123-126.
DOI：

REN Gui-lin, HAN Li, WANG Xiao-ping, et al. Determination of Monoester-alkaloids from Aconiti Kusnezoffii Radix Cocta in Xiaojin Wan[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 123-126. DOI： 10.13422/j.cnki.syfjx.2014210123.

摘要

目的: 通过比较不同厂家及批号小金丸中单酯型生物碱类成分的含量

为该制剂的临床用药安全提供参考。方法: 建立小金丸中制草乌单酯型生物碱类成分(苯甲酰新乌头原碱、苯甲酰乌头原碱和苯甲酰次乌头原碱)的HPLC含量测定方法

流动相乙腈-20 mmol·L-1磷酸二氢钠(用三乙胺调节pH 6.5)(47:53)

检测波长235 nm。比较4个厂家生产的8批样品中3种生物碱类成分含量。结果: 3种生物碱类成分线性范围均为4~60 mg·L-1

加样回收率分别为98.42%

101.79%

102.13%。3种单酯型生物碱总质量分数最高达214.718 μg·g-1

最低值18.452 μg·g-1。结论: 不同厂家和同一厂家不同批次样品中3种生物碱的含量存在较大差异

可能与原材料质量、制剂工艺及生产设备等因素有关。

Abstract

Objective: To compare monoester-alkaloids content of different batches of Xiaojin Wan from different manufacturers and provide a reference for clinical drug safety of this preparation. Method: Determination of monoester-alkaloids from Aconiti Kusnezoffii Radix Cocta in Xiaojin Wan was established

including benzoylmesaconine

benzoylaconine and benzoylhypacoitine;mobile phase was consisted of acetonitrile-20 mmol·L-1 sodium dihydrogen phosphate(adjusted pH to 6.5 with triethylamine)(47:53)

detection wavelength was set at 235 nm.The content of these three components in 8 batches of Xiaojin Wan from four manufacturers was compared. Result: Linear ranges of these three components were 4-60 mg·L-1

recoveries were 98.42%

101.79% and 102.13%

respectively.Total content of these three components was up to 214.718 μg·g-1with the lowest value of 18.452 μg·g-1. Conclusion: There is a big difference among 3 kinds of monoester-alkaloids from different manufacturers and different batches of the same manufacturer

which may be related to quality of raw materials

preparation process

production equipment and other factors.

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