Treatment of 42 Cases with Deep Vein Thrombosis Formation by Integrated Traditional Chinese and Western Medicine

LI Jian-peng; WANG Da-wei

doi:10.13422/j.cnki.syfjx.2014210209

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Treatment of 42 Cases with Deep Vein Thrombosis Formation by Integrated Traditional Chinese and Western Medicine

更新时间：2024-01-04

- Treatment of 42 Cases with Deep Vein Thrombosis Formation by Integrated Traditional Chinese and Western Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 21, Pages: 209-212(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014210209
  CLC： R543.6
- Published：2014
- 稿件说明：
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LI Jian-peng, WANG Da-wei. Treatment of 42 Cases with Deep Vein Thrombosis Formation by Integrated Traditional Chinese and Western Medicine[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 209-212.
DOI：

LI Jian-peng, WANG Da-wei. Treatment of 42 Cases with Deep Vein Thrombosis Formation by Integrated Traditional Chinese and Western Medicine[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 209-212. DOI： 10.13422/j.cnki.syfjx.2014210209.

摘要

目的: 探讨通脉消栓汤联合西医常规疗法治疗深静脉血栓形成(DVT)的疗效及作用机制。方法: 将84例DVT患者随机按住院前后分为西药组和观察组各42例。西药组使用低分子肝素钙

5 000 U

皮下注射

1次/d;巴曲酶注射液5 Bu

静脉滴注

隔日1次;拜阿司匹林肠溶片

100 mg/次

1次/d

晚餐后服用;前列地尔注射液

10 mL

静脉推注。观察组在西药组治疗的基础上加用通脉消栓汤

1剂/d。两组疗程均为2周。检测凝血酶原时间(PT)

活化部分凝血活酶时间(APTT)

纤维蛋白原(FIB)和血小板(PLT)及血浆 D-二聚体(D-D)水平;观察疼痛、肿胀、体征变化情况

采用彩色超声多普勒血管显像检测治疗静脉通畅情况;进行治疗前后血液流变学指标检测。结果: 经有序资料卡方检验

观察组临床疗效优于西药组(P<0.05);治疗后第7

14天两组PT

APTT

FIB

PLT及D-D均比治疗前下降(P<0.01)

观察组在第7

14天FIB和D-D均低于西药组(P<0.01);治疗后第7

14天两组疼痛、肿胀、体征及静脉通畅情况均比治疗前有所降低(P<0.01)

观察组疼痛、肿胀、体征及静脉通畅情况评分均低于同期西药组(P<0.01);治疗后两组全血黏度、血浆黏度、血沉和全血还原黏度均比治疗前有所改善(P<0.01)

观察组的改善优于西药组(P<0.01)。结论: 通脉消栓汤促进了静脉通畅、缓解了DVT症状和体征

临床疗效作用机制可能与改善血液循环

促进血栓的溶解和血管的再通有关。

Abstract

Objective: To discuss the effect and action mechanism of integrated Tongmai Xiaoshuan decoction and conventional western medicine on patients with deep vein thrombosis (DVT). Method: Eighty-four patients with DVT were randomly divided into observation group (42 cases) and western medicine group (42 cases) by random number table. Patients in western medicine group receivedv 5000 U low-molecular-weight heparins calcium injection (hypodermic injection) once daily

5 Bu batroxobin injection (intravenous drip) every other day

100 mg bayaspirin enteric-coated tablets once daily after dinner and 10 mL alprostadil injection (intravenous injection). Based on the treatment of western medicine group

patients in observation group added 1 dose Tongmai Xiaoshuan decoction once daily. All patients in both groups received 2 week periods of treatment. The prothrombin time (PT)

activated partial thromboplastin time (APTT)

fibrinogen (FIB)

platelet (PLT) and plasma D-two dimer(D-D)level were detected. Changes of pain

swell

sign and venous flow situation were observed

and patency of veins was detected by color Doppler flow imaging. The blood rheology target was tested before and after treatment. Result: The observation group showed a better effect than western medicine group through order information chi-square test (P<0.05). The PT

APTT

FIB

PLT and D-D levels in both groups declined compared with those before after 7 and 14 days of treatment (P<0.01). Besides

FIB and D-D levels in observation group were lower than those in western medicine group at days 7 and 14 after treatment (P<0.01). Moreover

the pain

swell

sign and venous flow situation in both groups were improved at days 7 and 14 afrer treatment compared with those before treatment (P<0.01). Besides

better effects were obtained in the observation group (P<0.01). The whole blood viscosity

plasma viscosity

blood sedimentation and whole blood reductive viscosity in both groups were improved compared with those before treatment (P<0.01). Besides

better effects were obtained in the observation group (P<0.01). Conclusion: Tongmai Xiaoshuan decoction could improve the patency of vein and relieve the symptoms and signs in patients with DVT. Its mechanism of action may be related to ameliorating blood circulation

promoting thrombolytic effects and recanalization of occluded vessels.

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Related Institution

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